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| Analysis of the mortality risk in septic shock patients with myocardial depression |
| Wu Ding-ye, Gao Song, Heng Jun-feng, Yan Jie |
| Intensive Care Unit, Wuxi People′s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China |
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Abstract Objective The purpose of this study was to analyze the death risk in septic shock patients with myocardial depression. Methods Patients with septic shock in our ICU were recruited during the year 2015 and 2016. Patients with EF< 50% were recruited to myocardial depression group, and the others were recruited to non-myocardial depression group. The differences of CRP, PCT, Lac which obtained within 6 hours of hospitalization between two groups were analyzed. The differences of CRP, PCT, Lac, BNP, cTnI, SOFA score, average dose of norepinephrine obtained within 24~48 hours of hospitalization between two groups were analyzed. Multivariate Cox regression analysis was used to analyze the death risk of septic shock patients and its difference between two groups. Results 132 patients were recruited in the study. Patients′ 24~48 h Lac, BNP, cTnI, SOFA scores and the average dosage of norepinephrineof the myocardial depression group were higher than those of the non-myocardial depression group, and the difference was statistically significant(P<0.05). Multivariate Cox risk regression analysis showed that 24~48 h Lac, BNP, cTnI, SOFA score, average dose of norepinephrine and myocardial depression were risk factors for death in septic shock patients, and the difference was statistically significant(P<0.05). 14 days′ death risk of the patients in the myocardial depression group was 95.2% significantly higher than that in the non-myocardial depression group(P<0.05). The Annual risk of death was analyzed in patients who were still alive after 14 days′hospitalization, and the difference between two groups was not statistically significant. Conclusion The 14 days′ mortality risk factors of septic shock patients are 24~48 h Lac, BNP, cTnI, SOFA, the average dose of norepinephrine, and myocardial depression. The risk of death for 14 days in patients with myocardial depression is increased by 95.2%. There is no difference in annual mortality risk between the patients who are still alive after 14 days′ hospitalization in two groups.
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Corresponding Authors:
Jie Yan, E-mail: yjeast@163.com
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