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| Evaluation of early prognosis of acute paraquat poisoning in patients with acute paraquat poisoning by peripheral blood NRL combined with PCT |
| Chen Hong-gang, Yang Rong-jia, Li Pei-hong, Wang Bin-bin |
| Department of Emergency, People′s Hospital of Gansu Province, Lanzhou 730000, China |
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Abstract Objective To explore the value of peripheral blood neutrophil/lymphocyte ratio (NLR) combined with procalcitonin (PCT) in the early prognosis of acute paraquat poisoning. Methods 60 cases of acute paraquat poisoning were selected as the observation group, and 30 healthy volunteers were selected as the control group. In the observation group, serum NLR and PCT levels were detected on the 1st, 3rd and 7th day admitted to the hospital. The serum NLR and PCT levels were detected in the control group on the day of physical examination. The prognosis of the patients within 1 month after poisoning was followed up, and then the patients were divided into the survival group and the death group. Spearman correlation analysis was used to analyze the relationship between NLR and PCT. Receiver operating characteristic (ROC) curves of serum NLR, PCT and their combined detection were drawn in order to analyze their prediction value for patient′s death after acute paraquat poisoning, and the area under the curve (AUC), the optimal critical value and the sensitivity, specificity, positive predictive value and negative predictive value were respectively calculated. Results There were 58 effective subjects in the observation group, of which 19 were in the death group and 39 in the survival group. In the 1D group, death group and survival group serum NLR and PCT levels were significantly higher than those in control group (P<0.01); serum levels of NLR, PCT in death group on 1st, 3rd and 7th day were increased gradually (P<0.05); in the survival group serum NLR, PCT levels on 3rd day were higher than those on 1st day and 7th day (P<0.05); serum NLR, PCT level in survival group on 1st, 3rd and 7th day were lower than the death group level (P<0.01). Spearman correlation analysis showed that the level of serum NLR in the observation group was positively correlated with the level of PCT (r=0.53, P<0.01). The area under the ROC curve predicted, sensitivity and specificity by NLR+PCT for patients with acute paraquat poisoning was significantly different from that of NLR and PCT (P< 0.05). The higher the NLR, PCT and NLR+PCT were, the greater possibility of death were in patients with acute paraquat poisoning. Conclusion Peripheral blood NLR combined with PCT detection is simple and convenient, easy to observe, and has high specificity and sensitivity of acute paraquat poisoning early prognosis assessment of patients with a high clinical value for patients with acute paraquat poisoning, clinical diagnosis, condition assessment, prognosis has certain reference significance.
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Corresponding Authors:
Yang Rong-jia, E-mail: 13909447906@139.com
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