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| Role of mitochondrial Sirt3 activation during severe hemorrhagic shock |
| Wang Qi, Zhao Zi-Gang, Niu Chun-Yu |
| Institute of Microcirculation, Hebei North University, Zhangjiakou 075000, China |
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Abstract Sirtuin 3 (Sirt3) is a mitochondrial enriched deacetylase. Activation of Sire3, which deacetylates transcription factors and cofactors, attenuates the severe hemorrhagic shock-induced vascular hypo-reactivity and vascular hyper-permeability, suppresses the injury of oxidative stress, inhibits cell necrosis and apoptosis, and alleviates the mitochondria damage and dysfunction, as a result, plays protective effects for tissues and cells. This review focuses on new data linking the activation of Sirt3 to management of severe hemorrhagic shock, and provides a novel implication for treatment of severe hemorrhagic shock.
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Corresponding Authors:
Niu Chun-Yu, E-mail: ncylxf@126.com. Zhao Zi-Gang, E-mail: zzghyl@126.com
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