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| The change and significance of neutrophil CD64 and thyroid hormone level in biliary tract infection |
| Li Yuan-li, Zhao Ji-bo, Li Fu-long, Huang Shu-wei, Li Shu-tie, Wang Ye-ming, Teng Jin-liang |
| First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China |
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Abstract Objective To investigate the change and significance of neutrophil CD64 and thyroid hormone level in biliary tract infection. Methods A total of 300 patients with biliary tract infection and 40 healthy people who received physical examination in our hospital from January 2015 to December -2017 were selected. According to whether operation, biliary infection patients were divided into operation group and non-operation group. The CD64 index of neutrophils in peripheral blood was detected by flow cytometry, and the levels of thyroid hormone related iodide (T3), thyroxine (T4), three iodide adenosine rT3 and thyroid gonadotropin (TSH) in peripheral blood were detected by biochemical assay at the time of admission, 1st day, 5th day and 14th day after admission. Results The CD64 index of neutrophils in peripheral blood of patients with biliary tract infection (28.65±3.25) was significantly higher than that of normal people (10.36±2.13). With the prolonged time, the CD64 index decreased significantly, and there was a significant difference compared with those of the healthy people (P<0.05). The expression level of T3 (0.58±0.11) nmol/L, rT3 (0.50±0.18) nmol/L, T4 (42.33±5.98) nmol/L, TSH (0.72±0.12) nU/L in peripheral blood of patients with biliary tract infection was significantly lower than that of healthy people T3 (1.63±0.52) nmol/L, rT3 (1.85±0.85) nmol/L, T4 (108.65±12.33) nmol/L, TSH (3.22±0.92) nU/L (P<0.05). The expression level of T3, T4, rT3 and TSH increased significantly with the prolongation of time. Cox regression analysis showed that the CD64 index and thyroid hormone level of neutral cells were closely related to the prognosis of biliary tract infection (P=0.006, 0.003, 0.003, 0.000,0.001). Conclusion The level of neutrophils CD64 and thyroxine in peripheral blood of patients with biliary tract infection is closely related to the prognosis of infection, which can be used as an independent prognostic indicator of biliary tract infection.
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| About author:: Li Yuan-li, E-mail:1154993383@qq.com |
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