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| The efficacy and safety of high flow nasal cannula in preterm neonatal apnea：a meta-analysis |
| iu Jing-jing, Zhu Lei, Liu Yi-shan, Xue Hong,Yue Han-xun, Liu Jian, Yang Ke-hu |
| The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China |
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Abstract Objective This systematic review aimed to evaluate the effect of high flow nasal cannula (HFNC) undergoing apnea of prematurity (AOP). Methods Using home and abroad databases to search all documents required. The deadline of retrieval was January, 2018. Then the studies were screened according to the inclusion and exclusion criteria. Data were analyzed by Stata 12.0software. Results 9 randomized controlled trials (RCT) and 1 quasi-randomized control trial (q-RCT) with 769 patients were eligible for analysis. Compared with control group, HFNC group can significantly reduce incidence of nose injury［OR=0.30, 95%CI(0.19, 0.48), P＜0.05］and air leakage syndrome ［OR=0.41, 95%CI(0.19, 0.88), P=0.022］, shorten the time of oxygen ［SMD=-0.51, 95%CI（-1.00,-0.02）, P=0.040］, but there was no significant difference in effective rates ［OR=1.15, 95%CI(0.89, 1.48), P=0.275］, intubation rate［OR=0.69, 95%CI(0.42, 1.13), P= 0.140］, the time of non-invasive ventilation［SMD=-0.35, 95%CI(-1.02, 0.31), P=0.297］and rate of other complications. Conclusion HFNC can reduce rate of nose injury, but there is still a large number of RCT evidence for the effectiveness and the incidence of other complications.
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Corresponding Authors:
Liu Jian, E-mail: medecinliu@sina.com
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