|
|
|
|
|
| Prognostic value of serum albumin and neutrophil/lymphocyte ratio in patients with traumatic cerebral hemorrhage |
| Zhuo Fen, Xiao Hua, Huang Juan-juan, Cai Yue-hong |
| Department of Clinical Laboratory, Third People′s Hospital of Hainan Province, Sanya 572000, China |
|
|
|
|
Abstract Objective To explore the prognostic value of serum albumin (Alb) and neutrophil/lymphocyte ratio (NLR) in patients with traumatic cerebral hemorrhage (TICH). Methods A total of 240 patients with TICH admitted to Hainan Third People′s Hospital were divided into survival group (n=187) and death group (n=53) according to the prognosis of 28 days. Alb and NLR levels were measured on the first, third and fifth days after admission. The ROC curve was used to analyze the predictive value of Alb and NLR at different time points for the death of TICH patients. Results Serum Alb levels in the death group on the first, third and fifth days were significantly lower than those in the survival group ［(32.75±5.62) g/L vs. (39.35±6.28) g/L, (29.30±4.58) g/L vs. (43.46±7.52) g/L, (22.37±4.20) g/L vs. (45.42±7.64) g/L, all were P<0.05). NLR in the death group was significantly higher than that in the survival group on the first, third and fifth days ［(6.03±2.35) vs. (4.36±1.34), (7.14±2.38) vs. (3.36±1.25), (8.50±3.25) vs. (2.14±0.92), all were P<0.05). The ROC curve showed that the optimal threshold values of serum Alb and NLR levels on the third day for predicting death in TICH patients were 31.40 g/L and 5.24, respectively. The AUC (95%CI) of the two combined ［0.924 (0.860-0.973)］ prediction of TICH death on the third day was significantly higher than that of single Alb ［0.834 (0.781-0.892)］ or NLR ［0.850 (0.780-0.897)］,with the sensitivity and specificity of 92.6% and 87.3%, respectively. Conclusion Alb and NLR levels were correlated with the condition of TICH patients, and the combination of the two items on the third day has a higher value in predicting the prognosis of TICH patients.
|
|
|
|
Corresponding Authors:
Zhuo Fen, E-mail: 537522864@qq.com
|
| About author:: Zhuo Fen, E-mail: 537522864@qq.com |
|
|
|
| ［1］Zhou YT, Tong DM, Wang SD, et al. Acute spontaneous intracerebral hemorrhage and traumatic brain injury are the most common causes of critical illness in the ICU and have high early mortality［J］. BMC Neurol, 2018, 18(1): 127.
［2］Limaye K, Yang JD, Hinduja A. Role of admission serum albumin levels in patients with intracerebral hemorrhage［J］. Acta Neurol Belg, 2016, 116(1): 27-30.
［3］Iglesias-Rey R, Rodríguez-Yáez M, Arias S, et al. Inflammation,edema and poor outcome are associated with hyperthermia in hypertensive intracerebral hemorrhages［J］. Eur J Neurol, 2018, 25(9): 1161-1168.
［4］Savarraj J, Parsha K, Hergenroeder G, et al. Early Brain Injury Associated with Systemic Inflammation After Subarachnoid Hemorrhage［J］. Neurocrit Care, 2018, 28(2): 203-211.
［5］中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2014)［J］. 中华神经科杂志, 2015, 48(6): 435-444.
［6］Leijdesdorff HA, van Dijck JT, Krijnen P, et al. Injury pattern, hospital triage, and mortality of 1250 patients with severe traumatic brain injury caused by road traffic accidents［J］. J Neurotrauma, 2014, 31(5): 459-465.
［7］Corps KN, Roth TL, McGavern DB. Inflammation and neuroprotection in traumatic brain injury［J］. JAMA Neurol, 2015, 72(3): 355-362.
［8］Leite HP, Rodrigues da Silva AV, de Oliveira Iglesias SB, et al. Serum Albumin Is an Independent Predictor of Clinical Outcomes in Critically Ill Children［J］. Pediatr Crit Care Med, 2016, 17(2): e50-57.
［9］姚光辉. 高龄急性心力衰竭患者入院早期中性粒细胞／淋巴细胞比值与近期心血管不良事件的相关性研究［J］. 中国急救医学, 2015, 35(5): 437-441.
［10］翟萌萌, 王建平, 余列, 等. 中性粒细胞与淋巴细胞比值对急性脑梗死患者预后的预测价值［J］. 中国脑血管病杂志, 2017, 14(2): 82-86.
［11］Guo Z, Yu S, Xiao L, et al. Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke［J］. J Neuroinflammation, 2016, 13(1): 199.
［12］Sun Y, You S, Zhong C, et al. Neutrophil to lymphocyte ratio 〖JP2〗and the hematoma volume and stroke severity in acute intracerebral〖JP〗 hemorrhage patients［J］. Am J Emerg Med, 2017, 35(3): 429-433.
［13］Martynov MI, Koplik EV, Shchukin IA, et al. Characteristics of serum albumin in patients with intracerebral hemorrhagic stroke［J］. Zh Nevrol Psikhiatr Im S S Korsakova, 2012, 112(8 Pt 2): 8-14.
［14］Giede-Jeppe A, Bobinger T, Gerner ST, et al. Neutrophil-to-Lymphocyte Ratio Is an Independent Predictor for In-Hospital Mortality in Spontaneous Intracerebral Hemorrhage［J］. Cerebrovasc Dis, 2017, 44(1-2): 26-34
［15］金子凡, 冯娟. 中性粒细胞与淋巴细胞比值对原发性急性脑出血患者短期预后的预测作用［J］. 中国脑血管病杂志, 2018, 15(5): 236-240,253. |
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 
