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| Research on the relationship between lymphopenia and the species of pathogenic bacteria and the underlying diseases in patients with bloodstream infection |
| Li Jian, Li Li-juan, Li Gang |
| Department of Anesthesiology, China-Japan Friendship Hospital, Beijing 100029, China |
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Abstract Objective To investigate the relationship between peripheral blood lymphocyte count and pathogenic bacteria species and underlying diseases in patients with bloodstream infection. Methods 204 patients with bloodstream infection were collected in our hospital ICU from January 2013 to April 2015 through a prospective study. Blood samples for peripheral total lymphocyte count were taken on the day of taking blood for the culture, according to peripheral total lymphocyte count was greater than 1.0×109/L, divided into lymphocyte >1.0×109/L group (61 cases) and lymphocyte< 1.0×109/L group (n=143).The patients′ age, gender, bacterial species, APACHE Ⅱ score, comorbidities and other differences were compared between the two groups, the rish factors affecting lymphopenia were analyzed by multivariate Logistic regression. Results The age, gender, albumin, pre-albumin concentrations, HGB, serum creatinine, serum phosphorus, D-dimer concentrations and comorbidities with cerebrovascular diseases, coronary heart disease, heart failure, diabetes mellitus, renal dysfunction, liver function abnormal in the lymphocyte<1.0×109/L group were not significantly different compared with those in the lymphocyte >1.0×109/L group (P>0.05);The procalciton in concentrations, proportion of enterococcal infection and proportion of associated with surgery or tumor in the lymphocyte< 1.0×109/L group were statistically significant higher than those in the lymphocyte >1.0×109/L group (P＜0.05). Enterococcal bloodstream infection in abdominal infection accounted for the major part (57.1%), followed by pulmonary infection (14.3%)and catheter-related infection(19.0%); Staphylococcus aureus bloodstream infection with pulmonary infection (58.6%), abdominal infection (10.3%), catheter infection (24.1%); Pseudomonas aeruginosa bloodstream infection occurred only in pulmonary infection.The Logistic regression analysis showed that age, tumor and hypophosphoremia were independent predictors of lymphopenia (P＜0.05). Conclusion Patients with bloodstream infection are often associated with lymphopenia(70.1%), when infection of abdominal combined with lymphopenia existence, we need to guard against enterococcus infection. The age, tumor and hypophosphoremia closely related to the lymphopenia with bloodstream infection.
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Corresponding Authors:
Li Li-Juan, E-mail: lilijuan236@126.com
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