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| Value of serum uric acid level in the differential diagnosis of epilepsy and syncope |
| Jiang Ming, Hu Hong-tao, Yan Xin, Yan Li-rong |
| Department of Neurology, Beijing Jishuitan Hospital, Beijing 100096, China |
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Abstract Objective To investigate the value of serum uric acid level in the differential diagnosis of epilepsy and syncope. Methods A total of 208 patients with epilepsy (106 patients)and syncope (102 patients) who visited the neurology emergency department of Beijing Jishuitan Hospital from November 2012 to April 2017 were enrolled into this study. Venous blood was collected within 12 hours of onset to measure the serum uric acid level by uricolase method. Results The serum uric acid level of the epilepsy group (529.28±202.35)μmol/L was significantly higher than that of the syncope group (306.84±76.02)μmol/L(t=10.417,P＜0.01). The proportion of elevated serum uric acid level in epilepsy group(71.70%)was significantly higher than that(8.82%)in syncope group(χ2=85.035,P＜0.01). Serum uric acid levels were negatively correlated with age in the epilepsy group(r=-0.302, P=0.002). Serum uric acid levels were not associated with age in the syncope group(P=0.653). 25 cases of epilepsy with elevated uric acid were followed up: serum uric acid levels dropped to normal within 3 days after the onset of epilepsy in 88% of the patients (22 patients), serum uric acid levels of the other 3 cases (12%) were significantly lower than before. Conclusion Serum uric acid level has certain clinical value for the differentiation of epilepsy and syncope.
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Corresponding Authors:
Hu Hong-tao, E-mail: hhtsd@163.com
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