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| Analysis of the correlation between PDW and severity and prognosis of patients with acute myocardial infarction |
| Li Rui-na, Li Hong, Li Bo |
| Department of Emergency, Affiliated Hospital of Henan Medical College, Xinzheng 451191, China |
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Abstract Objective To investigate the correlation between platelet distribution width (PDW)and severity and prognosis of patients with acute myocardial infarction (AMI). Methods A total of 297 AMI patients were selected in our hospital from June 2015 to June 2016.According to the PDW level, they were divided into low PDW group (less than 17%) and high PDW group (PDW>17%), with 144 cases and 153 cases, respectively. Comparing the two groups of patients with hypertension, hyperlipidemia, diabetes, heart rate, serum creatinine and other basic information, Killip classification, congestive heart failure, cardiogenic shock and death within 1 years or the incidence of re infarction, in-hospital mortality and mortality within 1 year. Results The high PDW group of the proportion of smoking history and grade Killip Ⅳ patients, congestive heart failure, cardiogenic shock, death or re-infarction within one year were higher than low PDW group (χ2=9.12,4.73,5.79,5.24,16.41,20.57;P＜0.05);the mortality rate during hospitalization was significantly higher than that in low PDW group (P＜0.05);the incidence of chest pain in KillipⅡ group was significantly lower than that in low PDW group(t=7.28, χ2=4.25;P＜0.05). Conclusion There is a significant positive correlation with AMI in patients with PDW disease severity, while patients with PDW increased, suggesting an increased risk of 1-year mortality and a higher incidence of re-infarction. Therefore, it helps to guide clinical treatment and improve the prognosis of patients with AMI.
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| About author:: Li Rui-na, E-mail: hzc63813@126.com |
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| ［1］Betgem RP, de Waard GA, Nijveldt R, et al. Intramyocardial haemorrhage after acute myocardial infarction［J］. Nat Rev Cardiol, 2015, 12(3):156-167.
［2］Gyngysi M, Wojakowski W, Lemarchand P, et al. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE)in patients with acute myocardial infarction based on individual patient data［J］. Circ Res, 2015, 116(8):1346-1360.
［3］Kennedy BB, Baird SM. Acute Myocardial Infarction in Pregnancy: An Update［J］. J Perinat Neonatal Nurs, 2016, 30(1):13-24.
［4］赵亚男, 王晨, 蔚有权,等. 氯吡格雷联合阿司匹林治疗急性心肌梗死的临床研究［J］. 中国临床药理学杂志, 2015, 47(8):595-598.
［5］沈卫峰, 沈迎, 张奇,等. 2015年《急性ST段抬高型心肌梗死诊断和治疗指南》解读［J］. 中国循环杂志, 2015, 30(Z2):23-25.
［6］陈冬生, 栾献亭, 杨进刚,等. 中国急性心肌梗死不同Killip分级患者的临床特征、治疗和预后情况分析［J］. 中国循环杂志, 2016, 31(9):849-853.
［7］Reichlin T, Cullen L, Parsonage WA, et al. Two-hour algorithm for triage toward rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T［J］. Am J Med, 2015, 128(4):369-379.
［8］de Couto G, Liu W, Tseliou E, et al. Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction［J］. J Clin Invest, 2015, 125(8):3147-3162.
［9］Noris P, Bertolino G, Previtali M, et al. Heparin infusion facilitates exvivo spontaneous platelet aggregation in patients with acute myocardial infarction who have undergone thrombolytic therapy［J］. Haemostasis, 1993, 23(4):185-191.
［10］Niccoli G, Scalone G, Lerman A, et al. Coronary microvascular obstruction in acute myocardial infarction［J］. Eur Heart J, 2016, 37(13):1024-1033.
［11］Burls A, Cabello JB, Emparanza JI, et al. Oxygen therapy for acute myocardial infarction: a systematic review and meta-analysis［J］. Emerg Med J, 2011, 28(11):917-923.
［12］Phan K, Phan S, Khuong JN,et al. Intra-aortic balloon pump therapy for acute myocardial infarction: Trial sequential analysis［J］. Int J Cardiol, 2016, 202:520-521.
［13］Woods KL, Ketley D, Agusti A, et al. Use of coronary angiography and revascularization procedures following acute myocardial infarction. A European perspective［J］. Eur Heart J, 1998, 19(9):1348-1354.
［14］Huang Z, Liu WJ, Guo QL, et al. Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia［J］. Genet Mol Res, 2015, 14(4):16074-16089.
［15］Togan T, Narci H, Turan H, et al. The impact of acute brucellosis on mean platelet volume and red blood cell distribution［J］. Jundishapur J Microbiol, 2015, 8(2):e20 039.
［16］Eicher JD, Wakabayashi Y, Vitseva O, et al. Characterization of the platelet transcriptome by RNA sequencing in patiertls with acute myocardial infarction［J］. Platelets, 2016, 27(3):230-239.
［17］Grove EL, Würtz M, Thomas MR, et al. Antiplatelet therapy in acute coronary syndromes［J］. Expert Opin Pharmacother, 2015, 16(14):2133-2147.
［18］Metharom P, Berndt MC, Baker RI, et al. Current state and novel approaches of antiplatelet therapy［J］. Arterioscler Thromb Vasc Biol, 2015, 35(6):1327-1338.
［19］Sevuk U, Altindag R, Bahadir MV, et al. Value of platelet indices in identifying complete resolution of thrombus in deep venous thrombosis patients［J］. Indian J Hematol Blood Transfus, 2015, 31(1):71-76.
［20］Qin C, Zhang H, Gu J, at al. Dynamic monitoring of platelet activation and its role in post-dissection inflammation in a canine model of acute type A uortic dissection［J］. Journal of Cardiothoracic Surgery, 2016, 11(1):1-5. |
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