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| Effects by different dose of Xuebijing Injection on early time NSE and S - 100 beta protein after cardiopulmonary resuscitation in rats |
| LIU Hai - jian, LU Shao - jun, Xu Zhi - yong, Huang Ding - ding, Liu Rong, Weng Hao |
| Department of Anesthesiology, South Branch of the Sixth Hospital affiliated Shanghai Jiao Tong University (Feng xian District Center Hospital), Shanghai 201499, China |
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Abstract Objective To observe the early effects by different dose of Xuebijing Injection on NSE and S - 100 beta protein after cardiopulmonary resuscitation(CPR) in rats. Methods 32 healthy SD rats aged 12 weeks weighting (300 ± 20)g were randomLy divided into 4 groups(n = 8 each). Group A (group operation - control): only intubated through the tracheal and the right femoral artery, saline 8 mL / kg were given after ROSC. Group B (group low dose ): saline 4 mL / kg + xuebijing 4 mL / kg were given after ROSC. Group C(group middle dose ): saline 2 mL / kg + xuebijing 6 mL / kg were given after ROSC. Group D ( group high dose ): xuebijing 8 mL / kg were given after ROSC. Time of CA and ROSC, ROSC proportion and the amount of saline and dopamine in 24 h were recorded . NSE and S - 100 beta protein were also measured 24 h later after ROSC. Results Compared with group A, the amount of saline and dopamine in 24 h, NSE and S - 100 beta protein were all lower in group B, C and D (P < 0. 05);Compared with group B, the amount of saline and dopamine in 24 h, NSE and S - 100 beta protein were all lower in groupC and D (P < 0. 05); but there were not significant difference in group C and D(P > 0. 05). Conclusion Xuebijing 6 mL / kg showed the excellent effect for the brain protection.
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Received: 03 August 2015
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Corresponding Authors:
WENG Hao, E - mail: wengwell@ 163. com
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