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| The role of non-thyroid illness syndrome in the severity and prognosis of sepsis |
| Shen Yan, Jiang Dai-shan, Wang Ting, Wang Meng, Shen Meng-zhu, Yuan Ding-shan, Shen Yan-bo, Huang Zhong-wei |
| Department of Emergency Medicine, the Affiliated Hospital of Nantong University, Nantong 226001, China |
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Abstract Objective To evaluate the role of non-thyroid illness syndrome (NTIS) in the severity and prognosis of sepsis. Methods A total of 110 patients with sepsis admitted to the emergence medical ward of our hospital from September 2015 to February 2018 were included in our study. We adopted retrospective method to analyze patients′ situations by statistical software. The patients were divided into NTIS group and those of normal group according to their thyroxin level on admission. We assessed the differences of baseline data and sequential organ failure assessment(SOFA) score between the two groups. We further analyzed 28-day Kaplan-Meier curve, clinical stabilization time and organ support needs between the two groups. Results There were no significant differences in baseline data. However, SOFA scores of NTIS group were significantly higher than those of normal group (score: 4.54±1.81 vs. 3.76±1.38, P＜0.05). Meanwhile, 28-day mortality of NTIS group was higher than that of normal group patients (23.3% vs. 5.4%, P＜0.05) as well. Furthermore, clinical stabilization time of NTIS group was higher than that of normal group(d:9.05±6.22 vs. 5.37±2.88，P＜0.01). Besides, NTIS group tended to high risk for organ support therapy especially renal replacement therapy. Conclusion NTIS with sepsis indicates more serious illness and worse prognosis. Thyroid hormone level test should be popularized in septic patients.
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| About author:: Shen Yan, E-mail：windshenyan@163.com |
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