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| Progress of relationship between IL-33/ST2 signaling and sepsis |
| Kong Xia, Zhang Xin-chao |
| Department of Emergency, Beijing Hospital, Beijing 100730, China |
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Abstract Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Soluble suppression of tumorigenicity 2 (sST2) concentrations could be increased in inflammatory diseases. This paper reviews the latest progress on the relationship between ST2/IL-33 signaling and sepsis, and has drawn the Conclusion that both the ST2 and IL-33 concentrations are increased in sepsis patients. Serum IL-33 concentration will change with the progress of sepsis; its trend of change is valuable in predicting the outcome of sepsis. These may have some research value and prospects in diagnosing sepsis.
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Received: 07 February 2017
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Corresponding Authors:
Zhang Xin-chao, E-mail: xinchaoz@163.com
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Zhongguancun, 
