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Clinical research of immune conditioning treatment of traumatic severe sepsis with multiple organ dysfunction syndromes |
Li Wen, Wang Dan-xin, Yu Zhuang-ming |
Affiliated Hospital of Hainan Medical College, Haikou 570102, China |
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Abstract Objective To observe the curative effect of immune conditioning treatment of traumatic severe sepsis with multiple organ dysfunction syndromes (MODS). Methods 86 patients with traumatic severe sepsis and MODS from January 2014 and July 2014 in our hospital were divided into two groups (43 cases in each group). The control group was given anti-inflammatory, antibacterial, rehydration, prevention of stress ulcer and continuous blood purification treatment, the observation group patients were treated in immune conditioning treatment on the basis of the control group. After 3 weeks treatment, the abdominal pain, abdominal distention, bowel movements, such as clinical symptoms, bowel sounds in two groups were observed, and the coagulation index of prothrombin time (PT), thrombin time (TT), activated partial thrombin time (APTT), the serum inflammatory factor levels of interleukin-6 (IL-6) and interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), and T lymphocyte subgroup percentage of CD4+, CD8+ and CD14+ were compared. After six months, the APACHE Ⅱ grade, MODS and mortality were observed. Results The cases of abdominal distension and abdominal pain in observation group were lower than control group, and bowel sounds and defecation frequency were higher than the control group (P<0.05). The PT, TT and APTT in the observation group were lower than the control group (P<0.05). The serum levels of TNF-α, IL-6, and IL-10 in the observation group were lower than the control group (P<0.05). The lymphocyte subgroup percentage of CD4+ and CD14+ were higher than the control group, the CD8+ was lower than the control group (P<0.05). After six months, the APACHE Ⅱ grade, MODS and mortality in observation group were lower than control group (P<0.05). Conclusion The immune conditioning treatment of traumatic severe sepsis with multiple organ dysfunction syndromes can significantly improve the clinical symptoms, reduce inflammation, improve blood coagulation function, regulate immune function; it has a good long-term curative effect.
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Received: 05 May 2017
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Corresponding Authors:
Yu Zhuang-ming, E-mail: yuzhuangm@sina.com
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