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| Comparison of two different anticoagulant methods in continuous renal replacement therapy in critically ill patients |
| Wang Jiao, Huang Jian, Li Yi-chen |
| Department of Emergency, Shenzhen People's Hospital & the Second Clinical Medical College of Jinan University, Shenzhen 518000, China |
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Abstract Objective To investigate and compare the effects of two different anticoagulant methods on continuous renal replacement therapy (CRRT) in critically ill patients. Methods From March 2015 to March 2017, 120 critically ill patients received continuous renal replacement therapy in our hospital. They were randomly divided into two groups: observation group and control group. The control group was treated with unfractionated heparin anticoagulant. The observation group was treated with low molecular weight heparin combined anticoagulation. The changes of electrolyte level before and after treatment and the serum creatinine APTT level before and after treatment were compared between the two groups. Filter life, anticoagulant daily expenses and adverse reactions were also recorded and compared between the two groups. Results The comparison of K+, Na+, Ca2+and Cl-level in the two groups before and after treatment was not obvious, and the difference in the comparison between groups was not statistically significant (all P>0.05). There was no significant difference in serum creatinine levels between the two groups before treatment (P>0.05). After treatment, the level of APTT in the observation group was (46.39±14.02)s, which was significantly lower than that in the control group (57.38 ±15.68)s. The difference between the two groups was statistically significant (P<0.05). The daily anticoagulant cost of the observation group was lower than that of the control group, and the differences between groups was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 3.33%(2/60), which was significantly lower than the control group 16.67% (10/60), and the difference between groups was statistically significant (P<0.05). Conclusion Neither of the two anticoagulant methods can seriously affect the electrolyte level in CRRT of critically ill patients, and the combination of low molecular weight heparin can effectively reduce the level of APTT in patients. At the same time, it significantly reduces medical costs and the occurrence rate of adverse reactions. Therefore, it is worthy of clinical application.
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| About author:: Wang Jiao, E-mail: 112615524@qq.com |
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