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| Epidemiology and application of sodium bicarbonate in patients with septic shock
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| Wang Guang-ying, Zhao Hao-tian, Long Ling, Wang Hua-wei, Jiang Xiao-zhi, He Fa-qiang, Zhang Zhi-yang, Zhao He-ling
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| Department of Graduate School of Hebei Medical University, Shijiazhuang 050017,China
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Abstract Sepsis shock is the common clinical problem of ICU critical patients.Sepsis can cause metabolic acidosis, but the physiological state of acidosis is not ideal, causing blood vessel elasticity decreased, myocardial depression. Bicarbonate is used to correct metabolic acidosis in patients with sepsis shock, but its applicable indications and curative effect is a controversial topic. This paper reviewed the current state of bicarbonate to sepsis shock acidosis and the effect of bicarbonate to various organ function such as lungs, heart and kidney.
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Received: 07 September 2017
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Corresponding Authors:
Zhao He-ling, E-mail: zhheling@sina.com
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| ［1］Ricci Z, Ronco C. Pathogenesis of acute kidney injury during sepsis ［J］. Curr Drug Targets, 2009, 10(12):1179-1183.
［2］朱大年，王庭槐.生理学［M］.第8版.北京：人民卫生出版社, 2015：218-224.
［3］Kraut JA, Madias NE. Lactic Acidosis: Current Treatments and Future Directions［J］. Am J Kidney Dis, 2016, 68(3):473-482.
［4］Kimmoun A, Novy E, Auchet T, et al. Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside ［J］. Crit Care, 2015, 19:175.
［5］Jung B, Rimmele T, Le Goff C, et al. Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study［J］. Crit Care, 2011, 15(5):R238.
［6］Cariou A, Vinsonneau C, Dhainaut JF. Adjunctive therapies in sepsis: an evidence-based review［J］. Crit Care Med, 2004, 32(11 Suppl):S562-570.
［7］Noritomi DT, Soriano FG, Kellum JA, et al. Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study［J］. Crit Care Med, 2009, 37(10):2733-2739.
［8］Adeva-Andany MM, Fernández-Fernández C, Mourio-Bayolo D, et al. Sodium bicarbonate therapy in patients with metabolicacidosis［J］. Scientific World Journal， 2014, 2014:627 673.
［9］Kim HJ, Son YK, An WS. Effect of sodium bicarbonate administration on mortality in patients with lactic acidosis: a retrospective analysis［J］. PLoS One, 2013, 8(6):e65 283.
［10］Lee SM, Kim SE, Kim EB, et al. Lactate clearance and vasopressor seem to be predictors for mortality in severe sepsis patients with lactic acidosis supplementing sodium bicarbonate: aretrospective analysis［J］. PloS One, 2015, 10(12):e0 145 181.
［11］Montagnani A, Nardi R. Lactic acidosis, hyperlactatemia and sepsis［J］. Italian J Med, 2016， 10(4):282-288.
［12］Taghizadieh A, Pouraghaei M, Moharamzadeh P, et al. Comparison of end-tidal carbon dioxide and arterial blood bicarbonate levels in patients with metabolic acidosis referred to emergency medicine［J］. J Cardiovasc Thorac Res, 2016, 8(3):98-101.
［13］El-Solh AA, Abou JP, Porhomayon J. Bicarbonate therapy in the treatment of septic shock: a second look［J］. Intern Emerg Med, 2010, 5(4):341-347.
［14］Dellinger RP, Levy MM, RhodesA, et al. Surviving sepsis campaign: international guidelines for management of severe sepsisand septic shock, 2012［J］. Crit Care Med, 2013, 41(2):580-637.
［15］Rhodes A,Evans LE, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016［J］. Intensive Care Med, 2017, 43(3):304-377.
［16］Boyd JH, Walley KR. Is there a role for sodium bicarbonate in treating lactic acidosis from shock ［J］. Curr Opin Crit Care, 2008, 14(4):379-383.
［17］Duman A, Akoz A, Kapci M, et al. Prognostic value of neglected〖JP〗 biomarker in sepsis patients with the old and new criteria: predictive role of lactate dehydrogenase［J］. Am J Emerg Med, 2016, 34(11):2167-2171.
［18］陈小枫, 叶纪录, 朱志云. 碳酸氢钠在感染性休克致低灌注性乳酸酸中毒时的分阶段应用［J］. 中华危重病急救医学, 2013, 25(1):24-27.
［19］Fang ZX, Li YF, Zhou XQ. Effects of resuscitation with crystalloid fluids on cardiac function in patients with severe sepsis［J］. BMC Infect Dis, 2008, 8:50.
［20］Marhong J, Fan E. Carbon dioxide in the critically ill: too much or too little of a good thing ［J］. Respir Care, 2014, 59(10):1597-1605.
［21］Cooper DJ, Walley KR, Wiggs BR, et al. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acid osis. A prospective, controlled clinical study［J］. Ann Intern Med, 1990, 112(7):492-498.
［22］Velissaris D, Karamouzos V, Ktenopoulos N, et al. The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate［J］. Crit Care Res Pract, 2015, 2015:605 830.
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