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| Interventional treatment of endovascular thrombolysis combined with mechanical thrombectomy in patients with acute ischemic stroke clinical effect and the impact of immune cell |
| Zhu Shen-hui, Li Jun |
| Department of Emergency, Changsha first Hospital, Changsha 410005, China |
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Abstract Objective To investigate the clinical effect of interventional treatment of intravascular thrombolysis combined with mechanical thrombectomy in patients with acute ischemic stroke and its effect on immune cells. Methods Eighty-four cases of acute ischemic stroke patients who were hospitalized in December-2017 January 2017 were prospectively studied. According to different treatment methods, 42 cases were divided into control group and 42 cases in observation group. The control group was treated with interventional intravascular thrombolysis, the observation group combined with mechanical thrombectomy, both groups were followed up for 3 months continuously, and the treatment effect was evaluated. The neurological deficits of both groups were evaluated by National Institute of Health Neurological Deficiency Inventory (NIHSS). The levels of CD3+, CD4+, CD8+and CD4+/CD8+immune cells in the two groups before and after treatment were measured by FACSCalbur flow cytometry. The levels of TIMI blood flow≥2, the residual stenosis rate, 24 h symptomatic intracranial hemorrhage, acute reocclusion and mortality after 3 months were recorded and statistically analyzed. The clinical curative effect and immune cell level influences. Results The intervention group treated with endovascular thrombolysis combined with mechanical thrombectomy 3 months, the effective rate was 92.86%, higher than the control group 73.18% (P<0.05). The scores of NIHSS in observation group were lower than those of control group Group(6.24±1.21 vs. 8.41±1.36, P<0.05). The levels of CD3+, CD4+and CD4+/CD8+in the observation group at 3 months after treatment were higher(64.63±4.69，46.86±4.06，2.26±0.42) than those in the control group(55.62±3.81,36.74±3.57, 1.49±0.29) (P<0.05). The levels of CD8+in the observation group at 3 months after treatment were lower than those in the control group (20.77±3.12 vs. 24.61±3.43,P<0.05). The TIMI blood flow≥2 (59.52% vs. 95.24%)level and acute reocclusion of blood(16.67% vs. 7.14%) in the observation group at 3 months after treatment were lower than the control group(P<0.05). Conclusion The interventional treatment of intravascular thrombolysis combined with mechanical embolectomy in patients with acute ischemic stroke help to improve clinical efficacy, reduce neurological deficits, improve immune cell level. It improves the prognosis of patients, it is of great worth to promote the application.
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| About author:: Zhu Shen-hui, E-mail：yongyuan4563@163.com |
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