集束化治疗对脓毒症相关性急性肾损伤的影响

doi:10.3969/j.issn.1002-1949.2019.07.009

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (7): 654-658 DOI: 10.3969/j.issn.1002-1949.2019.07.009

Influence of care bundle on sepsis related acute kidney injury

Wang Jing-jing, Li Jing, Wang Yong-qiang, Dou Lin

Intensive Care Unit, Tianjin First Central Hospital, Tianjin 300192, China

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Abstract Objective To analyze whether care bundle therapy guided by neutrophil gelatinase-associated apolipoprotein (NGAL) can improve the prognosis of septic associated acute kidney injury(AKI). Methods Sepsis patients with NGAL>130 ng/mL were enrolled. They were divided into the standard treatment group and the care bundle treatment group. The basic clinical features and prognosis of the two groups were observed. Results ①Compared to the standard treatment group, the care bundle treatment group infused more fluid on the first day［(4078±849）mL vs.（2664±828）mL， P<0.001］. Nevertheless, the care bundle treatment group infused less fluid on the third day ［(2277±733)mL vs. (3086±1056)mL, P<0.001］. ②The ratio of lung protective ventilation was much higher in care bundle management group (100.0% vs. 87.9%, P<0.001). And the non-mechanical ventilation time was much longer (22 d vs. 19 d, P<0.001). ③The care bundle treatment group had shorter length stay in ICU (9.5 d vs. 10 d, P=0.002) and lower kidney replacement rate (30.9% vs. 45.5%,P=0.014). Conclusion Care bundle management can shorten the length of stay in ICU and improve the recovery rate of renal function.

Key words： Acute kidney injury(AKI) KDIGO guideline Neutrophil gelatinase-associated apolipoprotein (NGAL) Sepsis Prognosis

Corresponding Authors: Dou lin, E-mail:doulint@163.com

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	Wang Jing-jing
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Cite this article:

Wang Jing-jing,Li Jing,Wang Yong-qiang, et al. Influence of care bundle on sepsis related acute kidney injury[J]. Chinese Journal of Critical Care Medicine, 2019, 39(7): 654-658.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.07.009 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I7/654

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