急性呼吸窘迫综合征炎症微环境对调节性T细胞分化的影响

doi:10.3969/j.issn.1002-1949.2019.05.019

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (5): 491-496 DOI: 10.3969/j.issn.1002-1949.2019.05.019

Effect of “inflammation microenvironment” on the differentiation of regulatory T cells in acute respiratory distress syndrome

Xie Ke, Lin Shi-hui, Xv Fang

Intensive Care Unit, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

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Abstract In acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), there is an "inflammatory microenvironment”, which composed of structure or functional cells of lung, immune cells including T cells, B cells and NK cells, macrophages and cytokines/inflammatory mediators secreted by the above cells. It plays an important and complex regulatory role in the development process of ARDS. Regulatory T cells (Tregs) is a subset of CD4+ T lymphocytes with uniquely functional, which is important to maintain immune homeostasis and self-tolerance. And it can play an important role in suppressing immune responses in ARDS. We could explore the key of Tregs differentiation from the cytokine-related regulation of the differentiation mechanism of Tregs in patients with ARDS. It will provide a new potential therapeutic targets for ARDS. This review will introduce the "inflammatory microenvironment” of ARDS, and its involvement in the differentiation of Tregs.

Key words： Acute respiratory distress syndrome (ARDS) Acute lung injury (ALI) Inflammation Microenvironment Regulatory T cells (Tregs)

Corresponding Authors: Xv Fang, E-mail: xufang828@126.com

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Xie Ke,Lin Shi-hui,Xv Fang. Effect of “inflammation microenvironment” on the differentiation of regulatory T cells in acute respiratory distress syndrome[J]. Chinese Journal of Critical Care Medicine, 2019, 39(5): 491-496.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.05.019 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I5/491

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