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| The correlation research between serum pentraxin-3 and the severity of sepsis |
| Zhang Jian-jie, Sun Bo, Sun Qin |
| Department of Intensive Care, Cixi Hospital, Wenzhou Medical University, Cixi 315300, China |
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Abstract Objective Assessing the correlation between pentraxin-3 (PTX-3) and the severity of sepsis patients. Methods Ninety-four cases with sepsis admitted to our hospital from March 2016 and March 2018 were analyzed. According to the severity of the patient′s condition, they were divided into sepsis and septic shock group. The differences in clinical parameters such as acute physiology and chronic health score Ⅱ(APACHE Ⅱ) and sequential organ failure score (SOFA) were compared between the two groups. Blood tests were performed to assess procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6), and PTX-3 on the first day and the third day of admission. The association of PTX-3 with inflammatory markers were respectively analyzed. The ROC curve was used to analyze the value of PTX-3 and PCT, CRP and IL-6 at different time points in judging the prognosis of sepsis. Results There were 64 cases of sepsis group and 30 cases of septic shock group. The septic shock group on the first and third days of admission, PTX-3, IL -6, CRP and PCT and other inflammatory indicators were significantly higher than the sepsis group (P＜0.001). Correlation analysis showed PTX-3 and CRP (r=0.716), PCT (r= 0.707) and IL-6 (r=0.868) all had significant correlations (all P＜0.001). The ROC curve analysis showed that the AUC of PTX-3 and IL-6 on the first day of admission were 0.893 (0.812-0.969) and 0.883 (0.813-0.954), respectively, which were significantly higher than those of CRP and PCT(P＜0.05). On the third day of treatment, the AUC of PTX-3 was as high as 0.912 (0.820-0.967), which was significantly higher than other inflammatory markers. The sensitivity and specificity were 92% and 93%, respectively (P＜0.001). Conclusion PTX-3 is related to sepsis-associated inflammatory markers and has a high sensitivity and specificity in predicting septic shock.
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Corresponding Authors:
Sun Qin, E-mail: icusunqin@163.com
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