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| Efficacy observation on alprostadil in treatment of myocardial injury and renal function by moderate and severe acute carbon monoxide poisoning |
| Jin Li-li, Qie Tao, Li Li-Qin |
| Department of Cardiology, the First Central Hospital of Baoding City, Baoding 071000, China |
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Abstract Objective To observe the early curative effect of alprostadil on myocardial injury renal function in patients with moderate and severe acute carbon monoxide poisoning. Methods From November 2015 to January 2018, 136 patients with moderate and severe acute carbon monoxide poisoning were enrolled in our study. The patients were randomly divided into the alprostadil group and the control group. Both groups were treated with hyperbaric oxygen, oxygen inhalation, preventing cerebral edema, and promoting brain cells function recovery. The patients in the alprostadil group were treated with alprostadil 10 μg once daily for 7 days. Indexes of myocardial ischemia and injury, electrocardiogram, cardiac function, renal function and early prognosis were observed in the two groups before and after treatment. Results There were significant differences in modified albumin (71.71±10.10) U/mL, creatine kinase MB (68.84±24.56) mg/mL and troponin I (1.12±1.56) ng/mL compared with control group after 6 hours of treatment with alprostadil (P<0.05). There was no statistical difference in myoglobin (Myo) between the two groups after alprostadil treatment. The QTc (430.75±7.82) ms and heart rate (67.59±8.54) beat/min were significantly improved compared with the control group (P<0.05) 7 days after alprostadil treatment. There was no significant difference in cardiac systolic function and diastolic function between the two groups. The cystatin C (0.57±0.17) mg/L was improved significantly compared with the control group (0.68±0.20) mg/L (P<0.05) 7 days after alprostadil treatment. There was no significant difference in early prognosis between the two groups. Conclusion Treatment of alprostadil could reduce myocardial ischemia, lower myocardial injury, improve glomerular filtration rate, and protect myocardium and renal function in the early stage of acute carbon monoxide poisoning. But there is no significant effect on cardiac function and early prognosis.
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| About author:: Jin Li-li, E-mail: 897648858@qq.com |
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| ［1］何涛.前列地尔注射液联合通心络胶囊治疗不稳定型心绞通的临床疗效观察［J］.中国医药, 2013, 8(1):17-18.
［2］韩坤.前列地尔治疗重症急性胰腺炎的临床效果及对肠道黏膜屏障功能和胃肠动力的影响［J］.中国医药, 2018, 13(9):1365-1368.
［3］王萍,刘畅,梅晰凡,等.前列地尔预处理大鼠心肌的抗心律失常与抗氧化效应分析［J］.哈尔滨医科大学学报, 2010, 44(4):341-343.
［4］杨薪,刘映峰,王世祥,等.前列地尔对慢性心衰大鼠心肌基质金属蛋白酶表达及纤维化的影响［J］.中国动脉硬化杂志, 2015, 23(3):266-270.
［5］曹新营,王志军,杨文琦,等.前列地尔对慢性心力衰竭大鼠的血流动力学及心肌胶原纤维的影响研究［J］.国际检验医学杂志, 2017, 38(15):2105-2108.
［6］黄洁,王德伟,石惠荣,等.前列地尔改善冠心病患者心肌微循环及血液流变学的疗效分析［J］.心血管康复医学杂志, 2017, 26(2):199-202.
［7］沈明亮, 陈英华,林永明.前列地尔治疗慢性肾衰竭的疗效分析［J］.中国现代药物应用, 2016, 10(21):71-73.
［8］刘超,胡晴,吴伟利,等.前列地尔注射液对行经皮冠状动脉介入治疗的冠心病并糖尿病肾病患者肾功能的影响［J］.实用心脑肺血管病杂志, 2016, 24(10):110-113.
［9］岳颖,金军,刘建卫,等.急性一氧化碳中毒急救的研究进展［J］.中国中医急症, 2012, 21(4):600-602.
［10］Inoue H, Aihara M, Tomioka M, et al. Specific enhancement of vascular endothelial growth factor (VEGF) production in ischemic region by alprostadil--potential therapeutic application in pharmaceutical regenerative medicine［J］. J Pharmacol Sci, 2013, 122(2):158-161.
［11］Soares BL, Freitas MA, Montero EF, et al. Alprostadil attenuates inflammatory aspects and leucocytes adhesion on renal ischemia and reperfusion injury in rats［J］. Acta Cir Bras, 2014, 2:55-60.
［12］Wei LY, Fu XH, Li W, et al. Effect of Intravenous Administration of Liposomal Prostaglandin E1 on Microcirculation in Patients with ST Elevation Myocardial Infarction Undergoing Primary Percutaneous Intervention［J］. Chin Med J (Engl), 2015, 128(9):1147-1150.
［13］Erer D, zer A1, DemirtaH,et al.Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats［J］. Drug Des Devel Ther, 2016, 10:2651-2658.
［14］刘洋,喻溥蛟,黄飞飞,等.前列地尔对改善急性心肌梗死PCI术后微循环及患者预后的影响［J］.国际心血管病杂志, 2017, 44(4):241-244, 252.
［15］王卉,张琼.前列地尔对慢性充血性心力衰竭患者心功能和血管内皮功能的影响［J］.中国疗养医学, 2018, 27(2):119-121.
［16］Li J, Wang JS, Xie ZX, et al. Correlations among copeptin, ischemia-modified albumin, and the extent of myocardial injury in patients with acute carbon monoxide poisoning［J］. Genet Mol Res, 2015, 14(3):10 384-10 389.
［17］赵庆丰,郝琳娟,杨乐,等.前列地尔对急性心肌梗死 PCI 术后心肌灌注的影响［J］.临床合理用药, 2016, 9(1):51-52.
［18］屈宝泽,王化洲.前列地尔对血管内皮保护作用的实验研究［J］.中国误诊学杂志, 2005, 5(13):2401-2402.
［19］Hsieh CC, Hsieh SC, Chiu JH, et al. Protective Effects of N-acetylcysteine and a Prostaglandin E1 Analog, Alprostadil, Against Hepatic Ischemia: Reperfusion Injury in Rats［J］. J Tradit Complement Med, 2014, 4(1):64-71.
［20］黄婷,陈刚,杨锴.慢性心力衰竭患者心室复极动态离散度的变化及意义［J］.疑难病杂志, 2014, 3(2):111-113.
［21］刘君,高磊,刘凌,等.前列地尔注射液对室间隔缺损介入治疗后血浆氨基末端脑利钠肽前体水平及心功能的影响［J］.中国动脉硬化杂志, 2014, 22(8):839-841.
［22］Svensson-Frbom P, Ohlson Andersson M, Almgren P, et al. Cystatin C identifies cardiovascular risk better than creatinine-based estimates of glomerular filtration in middle-aged individuals without a history of cardiovascular disease［J］. J Intern Med, 2014, 275(5):506-521.
［23］Salgado JV, Souza FL, Salgado BJ. How to understand the association between cystatin C levels and cardiovascular disease: Imbalance, counterbalance, or consequence［J］. J Cardiol, 2013, 62(6):331-335.
［24］张忠臣,吴丽丽,陈霞,等.前列地尔对2型肝肾综合征患者肾血流、血管活性物质的影响［J］.中国临床药理学杂志, 2015, 31(12):1095-1098.
［25］刘玉才,徐飞.前列地尔治疗糖尿病肾病的机制及临床应用［J］.中国老年学杂志, 2016, 36(2):500-501.
［26］丁捷.前列地尔改善慢性肾衰竭患者肾功能的作用［J］.航空航天医学杂志, 2016, 27(6):688-690. |
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