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| Change and significance of D- dimer in patients with hemorrhagic fever with renal syndrome |
| Zhuang Wei-huang，Huang Mao-juan |
| Department of Hematology，the Second Affiliated Hospital of Fujian Medical University，Quanzhou 362000，China |
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Abstract Objective To explore changes and clinical significance of plasma D-dimer in pa⁃ tients with hemorrhagic fever with renal syndrome（HFRS）. Methods A total of 52 HFRS patients at dif⁃ ferent stages were included in our study. The immunoturbidimetry were used to detect the levels of plas⁃ ma D-dimer，respectively which were compared with platelet，serum creatinine，and those of the healthy individuals. Results The levels of D-dimer in the HFRS patients at the pyretogenesis stage were sig⁃ nificantly higher than those in the healthy individuals（P＜0.01），and the levels at the diuretic stage and recovery stage were gradually declined and returned to normal. The D-dimer level in the heavy and criti⁃ cal ill patients was obviously higher than that in the light and moderate ill patients. The levels of D-di⁃ mer in the HFRS patients were significantly negative correlated to the platelet count（P＜0.01）and posi⁃ tive correlate to the levels of serum creatinine（P＜0.01）. Conclusion The levels of D-dimer in the HFRS patients are closely related to the progression and severity of the disease. It can be concluded that the detection of plasma D-dimer in the HFRS patients can be conducive to the early diagnosis，condition analysis，and prognosis.
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Received: 16 December 2015
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Corresponding Authors:
Huang Mao-juan，E-mail: 754878024@qq. com
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