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| Research progress of poly（ADP-ribose）polymerase in critical disease |
| Yu Jia, Wang Wei-xing |
| Department of Endoscopic Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan 430060,China |
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Abstract Poly（ADP-ribose）polymerase（PARP）plays a vital role in DNA repair and genome stability in eukaryotic cells. Over-activation of PARP is involved in the pathophysiological processes of gene regulation, signal transduction and cell apoptosis, and plays an important role in the process of acute inflammation. This paper reviews the structure and biological function of PARP, and study progress of PARP as a therapeutic target in several acute severe diseases such as ischemia-reperfusion injury,multiple organ failure, shock, and acute pancreatitis. Besides, it also summarizes the roles and possible mechanisms of PARP and its inhibitors in acute critical illness.
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Received: 16 February 2017
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Corresponding Authors:
Wang Wei-xing, E-mail: sate.llite @163.com
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