亚甲蓝对脑缺血再灌注损伤保护机制的研究进展

doi:103969/jissn1002-1949201809019

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (9): 827-832 DOI: 103969/jissn1002-1949201809019

Research progress on the protective mechanism of methylene blue against cerebral ischemia and reperfusion injury

Su Cheng-yang, Yin Lu-lu, Li Xiao-yan, Zhong Chun-ting, Geng Nan, Pang Yan, Li Pei-jie, Cao Wen

Intensive Care Unit, the Second Hospital of Lanzhou University, Lanzhou 730030, China

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Abstract Brain is the most sensitive organ to ischemia and hypoxia of human body. Various causes of cerebral ischemia, can cause ischemic injury to the brain, but in the subsequent treatment of reperfusion after reperfusion will cause a large number of reactive oxygen species produced through a variety of molecular mechanisms ultimately lead to neuronal cells necrosis or apoptosis initiating reperfusion injury. Methylene blue is a hotspot drug for the study of nervous system diseases. It has antioxidant properties and can quickly cross the blood-brain barrier and has a protective effect on neurons in the brain. This article reviews the mechanism of cerebral ischemia-reperfusion injury and the protective mechanism of methylene blue on cerebral ischemia-reperfusion injury.

Key words： Cerebral ischemia/reperfusion（I/R） injury Methylene blue (MB) Reactive oxygen species (ROS)

Corresponding Authors: Li Pei-jie, E-mail: lipeijielanzhou@hotmail.com

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	Su Cheng-yang
	Yin Lu-lu
	Li Xiao-yan
	Zhong Chun-ting
	Geng Nan
	Pang Yan
	Li Pei-jie
	Cao Wen

Cite this article:

Su Cheng-yang,Yin Lu-lu,Li Xiao-yan, et al. Research progress on the protective mechanism of methylene blue against cerebral ischemia and reperfusion injury[J]. Chinese Journal of Critical Care Medicine, 2018, 38(9): 827-832.

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http://www.cnemergency.org.cn/EN/103969/jissn1002-1949201809019 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I9/827

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