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Role and mechanism of reactive oxygen species in hemorrhagic shock-induced acute lung injury |
SUN Hong, ZHAO Zi-Gang, LI Shu-Guang, NIU Chun-Yu |
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Abstract Reactive oxygen species(ROS)plays strong oxidation, which is produced during aerobic cells metabolism. Lung is an early damaged organ following hemorrhagic shock. ROS produced from polymorphonuclear neutrophils, pulmonary microvascular endothelial cells and alveolar macrophages,causes oxidative stress reaction, expands inflammatory response, increases apoptosis, damages vascular permeability, and subsequently results in acute lung injury(ALI). The present article reviews the role and mechanism of ROS in hemorrhagic shock- induced ALI, therefore, provides a novel approach for treatment of hemorrhagic shock-induced ALI through ROS.
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Received: 11 June 2016
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