长链非编码RNA在脓毒症性心肌病中的潜在作用与意义

doi:doi:10.3969/j.issn.1002-1949.08.021

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (8): 809-812 DOI: doi:10.3969/j.issn.1002-1949.08.021

The potential role and significance of longchain non-coding RNA in sepsis induced cardiomyopathy

Zhang Ling, Zhang Hai-dan, Zhao Jing, Xiao Dan-yang, Li Pei-wu

Department of Emergency Medicine, the Second Hospital of Lanzhou University, Lanzhou 730000, China

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Abstract Sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The mortality rate is still high, and the increasing mortality caused by sepsis induced cardiomyopathy (SIC) is a great challenge for emergency and critical care medicine. The “inflammatory waterfalls” are closely related to the “genetic storms” in sepsis. Long chain non-coding RNAs (lncRNAs) have important effects on sepsis and SIC by regulating the inflammatory reactions and immune regulation processes. This article reviews the inflammatory regulation mechanism of lncRNAs in SIC recently.

Key words： Sepsis Sepsis induced cardiomyopathy (SIC) Longchain non-coding RNA (lncRNAs) Inflammatory regulation

Corresponding Authors: Li Pei-wu, E-mail: wuzi360@126.com

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Cite this article:

Zhang Ling,Zhang Hai-dan,Zhao Jing, et al. The potential role and significance of longchain non-coding RNA in sepsis induced cardiomyopathy[J]. Chinese Journal of Critical Care Medicine, 2019, 39(8): 809-812.

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http://www.cnemergency.org.cn/EN/doi:10.3969/j.issn.1002-1949.08.021 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I8/809

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