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| Clinical study of platelet-to-lymphocyte ratio among critically ill patients with acute kidney injury
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| Wang Xiao-juan, Lu Shi-qi, Xu Jin-bu, Cheng Ya-juan, Liu Lu
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| Department of Intensive Care Unit, the Second People′s Hospital of Lianyungang, Lianyungang 222023, China
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Abstract Objective To discuss the clinical value of platelet-to-lymphocyte ratio (PLR) for critically ill patients with acute kidney injury (AKI). Methods A total of 280 AKI cases were identified, these patients were admitted by Intensive Care Unit of the Second People′s Hospital of Lianyungang from June 2015 to June 2017. Patients were divided into different subgroups according to the stages of AKI, compare PLR, neutrophil-to-lymphocyte ratio (NLR) and some other indexes among groups. Then, Spearman correlation analysis was conducted between indexes such as PLR, NLR and scores of Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) and Sequential Organ Failure Assessment (SOFA). In the end, receiver operating characteristic (ROC) curves of PLR and NLR was obtained, and the optimal cut-off point of PLR was calculated. Results ①It is shown that the level of PLR increased as the stages of AKI getting higher through data analysis of the three subgroups AKI stage 1, AKI stage 2 and AKI stage 3, the difference was statistically significant ( P < 0.05 ). ②Through Spearman correlation analysis, there was a moderate positive correlation between PLR and scores of APACHE Ⅱ and SOFA (spearman correlation coefficient was 0.432, 0.417, respectively). ③ROC curve of PLR was closer to top left corner than the curve of NLR. AUC of PLR was 0.783 and AUC of NLR was 0.639. According to the ROC curve, the optimal cut-off point of PLR was 293, its sensitivity was 77.6%, its specificity was 82.6%, and 95% CI was 0.712-0.854. Conclusion ①The level of PLR is associated with the stages of AKI and the severity of the disease. ②PLR is more accurate than NLR in predicting unfavorable prognosis in patients with AKI, and it could be used as an indicator in predicting prognosis.
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Corresponding Authors:
Lu Shi-qi, E-mail: lushiqi2004@126.com
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