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| Progress of relationship between MAPK signal transduction pathway and hemorrhagic shock |
| Song Qi, Wang Zhen-jie |
| Department of Emergency Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China |
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Abstract Objective Mitogen-activated protein kinases (MAPKs) signal transduction pathway is an important signal transduction pathway widely present in eukaryotic cells. It is stimulated by a variety of signaling molecules such as growth factors, cytokines, neurotransmitters, hormones and cellular stressors, which are activated by phosphorylation. Activated MAPKs can participate in stress response, cell proliferation, differentiation, migration and apoptosis and other physiological processes. The pathophysiological changes in hemorrhagic shock include not only hemodynamics, but also part of the inflammatory response and organ damage caused by ischemia-reperfusion after shock. The treatment of hemorrhagic shock not only satisfied with the control of bleeding and fluid recovery to restore tissue perfusion, should pay attention to its inflammatory response, prevention of multiple organ dysfunction. With the study of traumatic and hemorrhagic shock and MAPK pathway, the relationship between MAPK signaling pathway and hemorrhagic shock is further clarified.More research and development of drugs targeting this pathway will be supported by better theoretical evidence.In this paper, the correlation between MAPK signaling pathway and hemorrhagic shock-induced organ damage, inflammatory response and clinical application prospects are briefly reviewed.
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Corresponding Authors:
Wang Zhen-jie, E-mail: ahbyfywzj@163.com
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