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| The evaluation of HDL during eepsis |
| Wei Min, Zhou Rong |
| First College of Clinical Medicine, Lanzhou University, Lan Zhou 730000,China |
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Abstract Sepsis is the main cause of in-hospital patient mortality,understanding of its pathological mechanism makes it possible for rapid diagnosis,accurate treatment and prognosis.Because multifunction of HDL,such as anti-inflammation, antioxidant,glucose control, etc. It is widely concerned as a new clue in the progress of sepsis.HDL participates in the process of generation,development and evolution of sepsis at some level. The specific role of HDL in sepsis needs to be verified through further investigations.
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Corresponding Authors:
Zhou Rong, E-mail: zhourong0204@163.com
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| ［1］Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012［J］. Intensive Care Med, 2013, 39(2):165-228.
［2］van Leeuwen HJ, Heezius EC, Dallinga GM, et al. Lipoprotein metabolism in patients with severe sepsis［J］. Crit Care Med, 2003, 31(5):1359-1366.
［3］Chien JY, Jerng JS, Yu CJ, et al. Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis［J］. Crit Care Med, 2005, 33(8):1688-1693.
［4］Lee SH, Park MS, Park BH, et al. Prognostic implications of serum lipid metabolism over time during sepsis［J］. Biomed Res Int, 2015, 2015:789 298.
［5］Angus DC, van der Poll T. Severe sepsis and septic shock［J］. N Engl J Med, 2013, 369(9):840-851.
［6］Cooney MT, Dudina A, De Bacquer D, et al. HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk［J］.Atherosclerosis, 2009, 206(2):611-616.
［7］Peshavariya H, Dusting GJ, Di Bartolo B, et al. Reconstituted high-density lipoprotein suppresses leukocyte NADPH oxidase activation by disrupting lipid rafts［J］. Free Radic Res, 2009, 43（8）:772-782.
［8］Nicholls SJ, Cutri B, Worthley SG, et al. Impact of short-term administration of high-density lipoproteins and atorvastatin on atherosclerosis in rabbits［J］. Arterioscler Thromb Vasc Biol, 2005, 25（11）:2416-2421.［9］Karavia EA, Hatziri A, Kalogeropoulou C, et al.Deficiency in apolipoprotein A-I ablatesthe pharmacological effects of metformin on plasma glucose homeostasisand hepatic lipid deposition［J］. Eur J Pharmacol, 2015, 766: 76-85.
［10］刘皓,刘秉文.载脂蛋白C研究进展［J］.中国动脉硬化杂志, 2002, 10（1）:76-80.
［11］王磊,宿红艳,明永飞,等.载脂蛋白D的结构、功能及临床应用［J］.细胞生物学杂志, 2008， 30(1):50-54.
［12］Saito H, Dhanasekaran P, Baldwin F, et al. Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particles［ J］. J Biol Chem, 2001, 276(44): 40949-40954.
［13］Singh K, Chaturvedi R, Asim M, et al. The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentiumin colonic epithelial cells by preventing NF-kappa B activation［ J］. J Biol Chem, 2008, 283 (24): 16752-16761.
［14］van den Elzen P,Garg S, León L, et al. Apolipoprotein-mediated pathways of lipid antigen presentation［J］. Nature, 2005, 437(7060): 906-910.
［15］Murphy AJ, Akhtari M, Tolani S, et al.ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice［J］. J Clin Invest, 2011, 121（10）:4138-4149.［16］Lagor WR, Brown RJ, Toh SA, et al. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo［J］. Arterioscler Thromb Vasc Biol, 2009, 29(1): 40-46.
［17］Lagor WR, Fields DW, Khetarpal SA, et al. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice［J］. PLoS One, 2012, 7(2): e31 616.
［18］Deakin JE, Papenfuss AT, Belov K, et al. Evolution and comparative analysis of the MHC Class Ⅲ inflammatory region［ J］. BMC Genomics, 2006, 7:281.
［19］Binkowska AM, Michalak G, Slotwinski R. Current views on the mechanisms of immune responses to trauma and infection［J］. Cent Eur J Immunol, 2015, 40(2):206-216.
［20］Kumaraswamy SB, Linder A, Akesson P,et al. Decreased plasma concentrations of apolipoproteinMin sepsis and systemic inflammatory response syndromes［J］. Crit Care, 2012, 16（2）:R60.
［21］Wolfrum C, Poy MN, Stoffel M. ApolipoproteinMis required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis［J］. Nat Med, 2005, 11（4）:418-422.
［22］Filippas-Ntekouan S, Liberopoulos E, Elisaf M. Lipid testing in infectious diseases: possible role in diagnosis and prognosis［J］. Infection, 2017, 45(5): 575-588.
［23］夏晓丹,唐朝克.失功能性HDL研究进展［J］.生理科学进展, 2016, 47(5):381-385.
［24］Tan Y，Liu TR，Hu SW ，et al．Acute coronary syndrome remodels the protein cargo and functions of high density lipoprotein subfractions［J］．P1oS one， 2014， 9(4)：e94 264．
［25］Tolle M, Huang T, Schuchardt M, et al. High-density lipoprotein loses its anti-inflammatory capacity by accumulation of pro-inflammatory-serum amyloid A［J］. Cardiovasc Res, 2012, 94(1): 154-162.
［26］钟建开,谭迎,陈盈文,等.同型半胱氨酸对高密度脂蛋白逆转运和抗氧化功能的影响［J］.中华老年心脑血管病杂志, 2016, 18(3):233-236.
［27］Gordon SM, McKenzie B, Kemeh G, et al. Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties［J］. Mol Cell Proteomics, 2015， 14(12): 3247-3257.
［28］Deckert V, Lemaire S, Ripoll PJ, et al. Recombinant human plasma phospholipid transfer protein (PLTP)to prevent bacterial growth and to treat sepsis［J］. Sci Rep, 2017, 7(1): 3053.
［29］Vaisar T, Tang C, Babenko I, et al. Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity［J］. J Lipid Res, 2015， 56(8): 1519-1530.
［30］Recalde D, Ostos MA, Badell E, et al. Human apolipoprotein A-IV reduces secretion of proinflammatory cytokines and atherosclerotic effects of a chronic infection mimicked by lipopolysaccharide［J］. Arterioscler Thromb Vasc Biol, 2004， 24(4): 756-761.
［31］Stan S, Delvin E, Lambert M, et al. Apo A-IV: an update on regulation and physiologic functions［J］. Biochim Biophys Acta, 2003， 1631(2): 177-187.
［32］Kohan AB, Wang F, Lo CM, et al. ApoA-Ⅳ: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety［J］. Am J Physiol Gastrointest Liver Physiol, 2015， 308(6): G472-481.
［33］Tran-Dinh A, Diallo D, Delbosc S, et al. HDL and endothelial protection［J］. Br J Pharmacol， 2013， 169(3):493-511.
［34］Zhang X, Wang L, Chen B. Recombinant HDL (Milano)protects endotoxin-challenged rats from multiple organ injury and dysfunction［J］. Biol Chem， 2015， 396(1):53-60.
［35］Tanaka S, Labreuche J, Drumez E, et al. Low HDL levels in sepsis versus trauma patients in intensive care unit［J］. Ann Intensive Care, 2017， 7(1): 60.
［36］Cirstea M, Walley KR, Russell JA, et al.Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis［J］. J Crit Care， 2017， 38:289-294. |
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