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| The value of early fibronectin on predicting the severity and prognosis in patients with severe pneumonia |
| Wu Hai-rong, Wu Xi-ping, Gao Shu-qin |
| Emergency Department, Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Wuxi 214071,China |
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Abstract Objective To explore early fibronectin(Fn) on predicting the prognosis in patients with severe pneumonia. Methods A retrospective observation study was conducted. Eighty-six patients of severe pneumonia admitted to emergency intensive care unit and intensive care units during January 2013 to January 2017 were enrolled. The data of serum Fn level, SOFA and CPIS scores were compared between survival and non-survival groups. The time of using vasoactive agents, mechanical ventilation, mortality rates and SOFA, CPIS scores were observed between Fn≤200 mg/L and Fn＞200 mg/L groups. The correlation was analyzed between Fn level and SOFA and CPIS scores. Results The serum Fn level, SOFA and CPIS scores had obvious changes between survival and non-survival groups (P<0.01, P<0.05). Compared with Fn＞200 mg/L groups, the time of using vasoactive agents, mechanical ventilation, mortality rates and SOFA, CPIS scores were significantly increased in Fn≤200 mg/L groups (P<0.05). The serum Fn level was significantly correlated with SOFA and CPIS scores. Conclusion Early monitoring of Fn is important for assessing the severity and prognosis and is helpful for evaluation of therapeutic effect on severe pneumonia.
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Received: 16 September 2017
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| ［1］Rello J, Perez A. Precision medicine for the treatment of severe pneumonia in intensive care［J］. Expert Rev Respir Med, 2016, 10(3):297-316.
［2］中国医师协会急诊医师分会. 中国急诊重症肺炎临床实践专家共识［J］.中国急救医学, 2016, 36(2):97-107.
［3］Leoni D, Rello J. Severe community-acquired pneumonia: optimal management［J］. Curr Opin Infect Dis, 2017, 30(2):240-247.
［4］陈珍,严启滔,郭振辉. 脓毒症炎症反应与内皮细胞损伤研究进展［J］. 国际免疫学杂志, 2016, 39(5):479-483.
［5］Zollinger AJ, Smith ML. Fibronectin, the extracellular glue［J］. Matrix Biol, 2017, 60-61:27-37.
［6］Hielscher A, Ellis K, Qiu C, et al. Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis［J］. PLoS One, 2016, 11(1):e0 147 600.
［7］Huang Q, Chen B, Wang F, et al. The temporal expression patterns of fibronectin and its receptors-α5β1 and αvβ3 integrins on blood vessels after cerebral ischemia［J］. Restor Neurol Neurosci, 2015, 33(4):493-507.
［8］Digiacomo G, Tusa I, Bacci M, et al. Fibronectin induces macrophage migration through a SFK-FAK/CSF-1R pathway［J］. Cell Adh Migr, 2017, 11(4):327-337.
［9］Monti M, Iommelli F, De Rosa V, et al. Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells［J］. PLoS One, 2017, 12(2):e0 171 362.
［10］Jun HK, Jung YJ, Choi BK. Inflammasome activators induce fibronectin expression and release in macrophages［J］. Cell Microbiol, 2017, 19(5)：1-11.
［11］Gortan Cappellari G, Barazzoni R, Cattin L, et al. Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes［J］. Sci Rep, 2016, 6:37 965.
［12］Yáez D, Izquierdo M, Ruiz-Perez F, et al. The Role of Fibronectin in the Adherence and Inflammatory Response Induced by Enteroaggregative Escherichia coli on Epithelial Cells［J］. Front Cell Infect Microbiol, 2016, 6:166. |
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