减阻剂在临床医学中的研究进展

doi:10.3969/j.issn.1002-1949.2018.10.018

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (10): 921-924 DOI: 10.3969/j.issn.1002-1949.2018.10.018

Progress in research on clinical medicine of drag-reducing polymers

Yin Lu-lu, Zhong Chun-ting, Su Cheng-yang, He Xiao-na, Li Xiao-yan, Li Pei-jie

Department of Intensive Care Medicine, Lanzhou University Second Hospital, Lanzhou 730030, China

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Abstract Drag-reducing polymers (DRP), a kind long-chain, soluble, non-toxic and high-molecular polymer, can reduce the fluid resistance without affecting the fluid viscosity . DRP have been widely used in drag reduction, such as petroleum, irrigation, fire and other industrial pipelines of. In recent years, DRP have been found in the field of medicine that it can obviously increase tissue microcirculation perfusion, and have important potential value in various diseases, especially in the ischemic vascular disease, hemorrhagic shock, stroke, diabetes and in other diseases. In this paper, we reviewed the progress in the application of drag reducer in clinical medicine.

Key words： Drag-reducing polymers (DRP) Ischemic vascular Disease Injury of brain;Shock Furosemide

Corresponding Authors: Li Pei-jie, E-mail: yll1593497603@163.com

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	Yin Lu-lu
	Zhong Chun-ting
	Su Cheng-yang
	He Xiao-na
	Li Xiao-yan
	Li Pei-jie

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Yin Lu-lu,Zhong Chun-ting,Su Cheng-yang, et al. Progress in research on clinical medicine of drag-reducing polymers[J]. Chinese Journal of Critical Care Medicine, 2018, 38(10): 921-924.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2018.10.018 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I10/921

［1］Coleman PB, Ottenbreit BT, Polimeni PI. Effects of a drag-reducing polyelectrolyte of microscopic linear dimension (Separan AP-273) on rat hemodynamics［J］. Circulation research, 1987, 61(6):787-796. ［2］Polimeni PI, Ottenbreit BT. Hemodynamic effects of a poly(ethylene oxide) drag-reducing polymer, Polyox WSR N-60K, in the open-chest rat［J］. J Cardiovasc Pharmacol, 1989, 14(3):374-380. ［3］Pacella JJ, Kameneva MV, Csikari M, et al. A novel hydrodynamic approach to the treatment of coronary artery disease［J］. Eur Heart J, 2006, 27(19):2362-2369. ［4］Sakai T, Repko BM, Griffith BP, et al. I.V. infusion of a drag-reducing polymer extracted from aloe vera prolonged survival time in a rat model of acute myocardial ischaemia［J］. Br J Anaesth, 2007, 98(1):23-28.  ［5］Hu F, Wang Y, Gong K, et al. Protective effects of drag-reducing polymers on ischemic reperfusion injury of isolated rat heart［J］. Clin Hemorheol Microcirc, 2016, 62(1):1-11. ［6］Faruqui FI, Otten MD, Polimeni PI. Protection against atherogenesis with the polymer drag-reducing agent Separan AP-30［J］. Circulation, 1987, 75(3):627-635. ［7］Sawchuk AP, Unthank JL, Dalsing MC. Drag reducing polymers may decrease atherosclerosis by increasing shear in areas normally exposed to low shear stress［J］. J Vasc Surg, 1999, 30(4):761-764. ［8］Chen X, Zha D, Xiu J, et al. A new hydrodynamic approach by infusion of drag-reducing polymers to improve left ventricular function in rats with myocardial infarction［J］. Int J Cardiol, 2011, 147(1):112-117. ［9］Bragin DE, Thomson S, Bragina O, et al. Drag-Reducing Polymer Enhances Microvascular Perfusion in the Traumatized Brain with Intracranial Hypertension［J］. Acta Neurochir Suppl, 2016, 122:25-29. ［10］Bragin DE, Peng Z, Bragina OA, et al. Improvement of Impaired Cerebral Microcirculation Using Rheological Modulation by Drag-Reducing Polymers［J］. Adv Exp Med Biol, 2016, 923:239-244. ［11］Bragin DE, Kameneva MV, Bragina OA, et al. Rheological effects of drag-reducing polymers improve cerebral blood flow and oxygenation after traumatic brain injury in rats［J］. J Cereb Blood Flow Metab, 2017, 37(3):762-775. ［12］Kameneva MV, Wu ZJ, Uraysh A, et al. Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments［J］. Biorheology, 2004, 41(1):53-64. ［13］Marhefka JN, Marascalco PJ, Chapman TM, et al. Poly(N-vinylformamide)-A drag-reducing polymer for biomedical applications［J］. Biomacromolecules, 2006, 7(5):1597-1603. ［14］邓哲, 曾红科, 冯永文, 等. 聚乙二醇4000对大鼠创伤性休克早期继发肠损伤的治疗作用［J］. 中国急救医学, 2015(2):157-160. ［15］席小丽, 陈仲清, 黃巧冰, 等. 聚乙二醇用于感染性休克早期大鼠液体复苏的实验研究［J］. 新乡医学院学报, 2011, 28(3):310-313.［16］胡振华, 陈仲清, 方琴. 聚环氧乙烷对脓毒症大鼠液体复苏的作用［J］. 中国急救医学, 2014(4):292-296. ［17］Smyth DD, Blandford DE, Jones DR, et al. Separan AP-273 and renal function: a novel natriuretic substance［J］. Can J Physiol Pharmacol, 1987, 65(9):2001-2003. ［18］Symth DD, Polimeni PI. Drag-reducing polymers: A novel class of diuretic and natriuretic compounds［J］. Cardiovasc Drugs Ther, 1990, 4(1):297-300. ［19］蔡淑敏, 曾振华, 傅卫军, 等. 减阻聚合物芦荟多糖对脓毒症大鼠肾功能的保护作用［J］. 临床麻醉学杂志, 2015, 31(11):1109-1112. ［20］Tohme S, Kameneva MV, Yazdani HO, et al. Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion［J］. Oncotarget, 2017, 8(35):59 854-59 866. ［21］Wang Y, Hu F, Mu X, et al. Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hypertension［J］. Biorheology, 2016, 53(1):13-22.