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| The relationship between red blood cell distribution width and blood lactate value in sepsis patients |
| Yao Bo, Liu Da-wei, Chai Wen-zhao, Wang Xiao-ting, Zhang Hong-min |
| Department of Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao 266000, China |
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Abstract Objective The study investigated whether red blood cell distribution width(RDW) is associated with tissue perfusion in sepsis patients. Methods A retrospective study was conducted of patients with sepsis admitted to the intensive care unit between May 2013 and February 2015. Clinical data, hemodynamic parameters, and laboratory data were recorded. Results A total of 300 patients with sepsis were included in the study, of whom 148 were assigned to the RDW-increased (RDW>15%) group and 152 to the RDW-normal (RDW ≤15%) group. Compared with the RDM-normal group, the RDW-increased group had a higher blood lactate concentration and contained a higher percentage of patients with lactate concentration>2.0 mmol/L at admission and 24 h later［2.1（1.1~3.7） mmol/L vs. 2.9（1.2~5.4）mmol/L，P=0.019；42.7%（65/152） vs. 56.8%（83/148），P=0.021；1.3（0.9~2.4）mmol/L vs. 1.6（1.1~3.5）mmol/L，P=0.039；24.5%（36/147） vs. 35.9%（55/153）, P=0.031］. But only a weak correlation was detected between RDW and lactate concentration at admission and 24 h later (r=0.154, P=0.008; r=0.124, P=0.031). In multiple linear regression analysis, RDW was not a factor affecting lactate value at admission and 24 h later. Conclusion The sepsis patients with high RDW have high lactate at admission and 24 h later, but RDW is not a factor affecting lactate value.
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Corresponding Authors:
Liu Da-wei, E-mail:dwliu98@163.com
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