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| Influence of aveolar-artery partial pressure on patients with ARDS caused by lung infection |
| Yu Yong-bo, Li Xing-hua, Wang Jing-jing, Wang Yong-qiang, Li Yin |
| Intensive Care Unit, Tianjin First Central Hospital, Tainjin 300192, China |
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Abstract Objective: To evaluate the effects of aveolar-artery partial pressure on ARDS patient′s ventilation weaning which was caused by lung infection. Methods: A retrospective analysis of 64 cases who were diagnosed ARDS caused by lung infection and required mechanical ventilation were selected; all patients were admitted to the ICU from July 2015 to July 2017 in our hospital. According to whether patients can wean ventilation or not, we divided these patients into two groups, the successful weaning ventilation group and the failure weaning ventilation group. We observed age, gender, creatinine (Cr), blood ALT, blood AST, total bilirubin (TBil), oxygenation index and aveolar-artery partial pressure (PA-aDO2) value of the two groups before mechanical ventilatory, and we also compared the two group′s oxygenation index and PA-aDO2 values on 1,3,7 and 14 day after mechanical ventilatory. The correlation between the oxygenation index and PA-aDO2 was compared in the two groups. Results: ①We found that the two group′s age, gender, serum creatinine (Cr), blood ALT, AST, total bilirubin (TBil), oxygenation index and PA-aDO2 values before the mechanical ventilation has no statistical difference, and there also has no statistical difference in oxygenation index and PA-aDO2 values on the first day after mechanical ventilation (P>0.05). ②There were statistical differences between the two group′s oxygenation index and PA-aDO2 values on the 3, 7, 14 day after mechanical ventilation (P<0.05), the successful weaning ventilation group′s oxygenation index was higher than that of the failure weaning ventilation group. The numbers were(163.65±25.33) mm Hg vs. (112.29±29.95) mm Hg, (172.68±22.09) mm Hg vs. (121.589±23.35) mm Hg, (231.9±37.56) mm Hg vs. (115.00±21.69) mm Hg, and it′s PA-aCO2 values were lower, the numbers were (186.65±55.05) mm Hg vs. (310.50±51.16) mm Hg, (120.41±33.91) mm Hg vs.(347.69±50.56) mm Hg, (86.38±29.91) mm Hg vs.(347.55±49.16) mm Hg. ③ The PA-aDO2 was significantly negatively correlated with the oxygenation index (r=-0.698, P=0.000). Conclusion: The dynamic monitoring of PA-aDO2 values is helpful for evaluation of the treatment effects and for predicting whether patients can wean ventilation or not, who was diagnosed ARDS caused by lung infection and require mechanical ventilation.
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Received: 26 September 2017
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Corresponding Authors:
Li Yin, E-mail: liyin0711@126.com
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