Objective To explore the effect of cytokines Qingyi decoction combining with continuous blood purification therapy on severe acute pancreatitis. Methods Aprospective double-blinded randomized controlled trial was conducted. Fifty-seven patients of severe acute pancreatitis admitted to department of critical care medicine of the second hospital of Lanzhou University were enrolled. They were randomly divided into control group(Qingyi decoction group, n=27)and study group(continuous blood purification therapy combining with Qingyi decoction group, n=30). Routine treatments were executed in bothgroups. 50 mLQingyi decoction was given thoughnasointestinal tube, and that was repeated every six hours in control group.Except Qingyi decoction, continuous blood purification therapy was executedin study group. While heparin used for anticoagulation,mode of that was continuous veno-veno hemofiltraion(CVVH).Using the improved formula of the General Hospital of Nanjing Military Region,dose of CVVH was 35 mL/(kg·h).Serum levels of creatinine(Scr), amylase(AMY), tumor necrosis factor-α(TNF-α), total bilirubin(TBIL), interleukin-1(IL-1), interleukin-6(IL-6), interleukin-8(IL-8)were assayed during the first and the seventh day of the treatment. At the same time nurses collected artery blood and monitored blood gas analysis and record arterial oxygen partial pressure(PaO₂),  bicarbonate ion(HCO ₃^-),fraction of inspired oxygen(FiO₂)and oxygenation index(PaO₂ /FiO₂).The test data were processed with SPSS 21.0 statistical software. Results The indicators of the first day ［AMY:(818±172)U/L vs.(813±111)U/L; BUN:(18.8±2.4)mmol/L vs.(18.4±2.1)mmol/L; Cr:(250±42)μmol/L vs.(244±59)μmol/L; TBIL:(41.1±9.3)μmol/L vs.(43.5±5.4)μmol/L; HCO ₃^-:(18.7±1.6)mmol/L vs.(18.5±1.7)mmol/L; TNF-α:(177.3±12.9)pg/L vs.(171.56±10.5)pg/L; IL-1(31.8±2.8)pg/L vs.(32.6±3.8)pg/L; IL-6:(111.3±22.8)pg/L vs.(119.4±10.6)pg/L; IL-8:(90.3±16.0)pg/L vs.(97.6±17.1)pg/L; PaO₂ /FiO₂:(269.7±61.7)mm Hg vs.(283.5±53.4)mm Hg］were not significantly different between the two groups(P＞0.05).After 7 days of treatment, experimental data confirmed that: The biochemical indexes of the control group ［AMY:(735±164)U/L, BUN:(17.1±2.1)mmol/L, Cr:(213±80)μmol/L, TBIL:(36.8±5.5)μmol/L, HCO:(20.1±1.8)mmol/L; TNF-α:(167.7±11.1)pg/L, IL-1:(27.7±5.4)pg/L, IL-6(92.7±29.2)pg/L, IL-8:(75.9±14.6)pg/L, PaO₂/FiO₂:(304.6±38.3)mm Hg］were decreased after treatment(P＜0.05). After treatment the biochemical indexes of the study group ［AMY:(649±149)U/L, BUN:(14.9±1.7)mmol/L, Cr:(127±50)μmol/L, TBIL:(32.1±4.7)μmol/L, HCO ₃^-:(21.3±1.7)mmol/L, TNF-α(120.4±7.9)pg/L, IL-1:(16.8±2.0)pg/L, IL-6(66.0±15.9)pg/L, IL-8:(64.9±11.8)pg/L, PaO₂/FiO₂:(330.2±50.5)mm Hg］were not only decreased(P＜0.05)but also lower than that of the control group(P＜0.05). The difference was statistically significant(P＜0.05). Conclusion Qingyi decoctioncombining continuous blood purification therapy can effectively reduce the level of inflammatory cytokines in patients with severe acute pancreatitis.