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| The treatment of acute radiation sickness |
| Xiong Feng, Xu Zhi-hui, Zhang Hai-hua, Li Fang |
| No. 211 Hospital of PLA, Harbin 150086, China |
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Abstract Nuclear incidents have threatened the world for decades, so that there is an urgent need to develop the safe and effective radiation countermeasures for acute radiation syndrome (ARS). Although a series of researches had been developed, few radiation countermeasures have been approved by the United States Food and Drug Administration (FDA). It is a complicated progress for treating radiation injuries which includes the hematopoietic, gastrointestinal and cerebrovascular therapies. Despite no way to identify all agents in this review, we emphasize some advanced development of existing radiation measures.
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Received: 18 August 2017
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Corresponding Authors:
泛应用，核武器、核恐怖活动、核设施事故对人们的核辐射损伤威胁逐步增加。对抗核辐射损伤，即急性放射病（ARS）药物的需求
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| ［1］Drr H, Abend M, Blakely WF, et al. Using Clinical Signs and Symptoms for Medical Management of Radiation Casualties - 2015 NATO Exercise ［J］. Radiat Res, 2017, 187(3): 273-286.
［2］Nagata S. The Cytokine Handbook ［M］. New York: Academic Press, 1994：371.
［3］Drouet M, Delaunay C, Grenier N, et al. Cytokines in combination to treat radiation-induces myelosuppression: evaluation of SCF+ glycosylated EPO+ pegylated G-CSF as an emergency treatment in highly irradiated monkeys ［J］. Haematologica, 2008, 93(3): 465-466.
［4］Liu JF, Du ZD, Chen Z, et al. Granulocyte colony-stimulating factor attenuates monocrotaline-induced pulmonary hypertension by upregulating endothelial progenitor cells via the nitric oxide system ［J］. Exp Ther Med, 2013, 6(6): 1402-1408.
［5］Farese AM, Cohen MV, Katz BP, et al. Filgrastim improves survival in lethally irradiated nonhuman primates ［J］. Radiat Res, 2013, 179(1): 89-100.
［6］Becker P, Schwebig A, Brauninger S, et al. Healthy donor hematopoietic stem cell mobilization with biosimilar granulocyte-colony-stimulating factor: safety, efficacy, and graft performance ［J］. Transfusion, 2016, 56(12): 3055-3064.
［7］Gluzman-Poltorak Z, Vainstein V. Recombinant interleukin-12, but not granulocyte-colony stimulating factor, improves survival in lethally irradiated nonhuman primates in the absence of supportive care: evidence for the development of a frontline radiation medical countermeasure ［J］. Am J Hematol, 2014, 89: 868-873.
［8］Culy CR, Spencer CM. Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemothera-py or radiotherapy and its potential therapeutic application in mylodysplastic syndrome ［J］. Drugs, 2001, 61(5): 641-684.
［9］Rasey JS, Spence AM, Badger CC, et al. Specific protection of different normal tissues ［J］. Pharmacol Ther, 1988, 39(1-3): 33-43.
［10］Miller RC, Murley JS, Grdina DJ. Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs ［J］. Radiat Res, 2014, 181(5): 464-470.
［11］Seed TM, Inal CE, Singh VK. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis ［J］. Int J Radiat Biol, 2014, 90(7): 594-604.
［12］Seed TM. Radiation protectants: current status and furture prospects ［J］. Health Phys, 2005, 89(5): 531-545.
［13］Singh VK, Hauer-Jensen M. γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status ［J］. Int J Mol Sci, 2016, 17(5): E663.
［14］de Freitas RB, Boligon AA, Rovani BT, et al. Effect of black grape juice against heart damage from acute gamma TBI in rats ［J］. Molecules, 2013, 18(10): 12 154-12 167.
［15］Ghosh SP, Kulkarni S, Hieber K, et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector ［J］. Int J Radiat Biol, 2009, 85(7): 598-606.
［16］Singh VK, Beattie LA, Seed TM. Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures ［J］. J Radiat Res, 2013, 54(6): 973-988.
［17］Kulkarni S, Chosh SP, Satyamitra M, et al. γ-Tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation ［J］. Radiat Res, 2010,173(6): 738-747.
［18］Suman S, Datta K, Chakraborty K, et al. Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival ［J］. Food Chem Toxicol, 2013, 60:488-496.
［19］Bai M, Ma X, Wang X, et al. The Accomlipation of NF-κB Lead to Radioresistance ［J］. Curr Protein Pept Sci, 2015, 16(4): 279-294.
［20］Wang Y, Park NY, Jang Y, et al. Vitamine Eγ-Tocotrienol inhibits cytokine-stimulated NF-κB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids ［J］. J Immunol, 2015, 195: 126-133.
［21］Ray S, Kulkarni SS, Chakraborty K, et al. Mobilization of progenitor cells into peripheral blood by γ-tocotrienol: a promissing radiation countermeasure ［J］. Int Immunopharmacol, 2013, 15(3): 557-564.
［22］Singh VK, Fatanmi, Wise, et al. The potentiation of the radioprotective efficacy of two medical countermeasures, γ-Tocotrienol and amifostine, by a combination prophylactic modality ［J］. Radiat Prot Dosimetry, 2016, 172(1-3):302-310.
［23］Stickney DR, Dowding C, Authier S, et al. 5‐androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression ［J］. Int Immunopharmacol, 2007, 7(4): 500-505.
［24］Kim JS, Jang WS, Lee S, et al. A study of the effect of sequential injection of 5-androstenediol on irradiation-induced myelosuppression in mice ［J］. Arch Pharm Res, 2015, 38(6): 1213-1222.
［25］Grace MB, Singh VK, Rhee JG, et al.5-AED enhances survival〖JP〗 of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis ［J］. J Radiat Res, 2012, 53(6): 840-853.
［26］Whitnall MH, Villa V, Seed TM, et al. Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice ［J］. Immunopharmacol Immunotoxicol, 2005, 27（1）:15-32. |
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