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| Clinical characteristics and the risk factors related to early prognosis of severe abdominal infection |
| WU Ming, LAI Kai, REN Di, LI Ming-li, ZENG jing-jing, WU Le-feng, HE Yun, FENG Yongwen |
| Department of Critical Care Medicine of Shengzhen Second Hospital, Shenzhen 518035, China |
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Abstract Objective To investigate the clinical characteristics and the risk factors for the early （two weeks）prognosis of patients with intra-abdominal infections. Methods Clinical data of 169 patients with severe abdominal infection，who were hospitalized during January 2000 and May 2015 in our hospital，were analyzed retrospectively. According to the outcome for two weeks，169 patients were di⁃ vided into two groups：the survivors 141 cases；the deceased 28 cases. Of which 127 cases were male and 42 females, mean age（78.6±12.8） years; The potential risk factors of severe abdominal infection patients were analyzed by univariate analysis and logistic regression analysis. Results Univariate analysis showed that the onset to surgery time, intra-operative liquid crystal colloid ratio, inappropriate initial antibiotic therapy, CD4, CD8 cells changes in one week, postoperative third days of net liquid, inadequate peritoneal drainage of intra-abdominal infection were risk factors for modality with severe abdominalinfection patients（all P＜0.05）．Survival group were（56.8±11.3）h, 1.17±0.03,11 cases, 105±36, 88± 26,（-839±217）mL and 7 cases; deceased group were（68.2±8.2）h, 3.13±0.18, 7 cases, -52±12, -54± 19,（1438±178）mL and 5 cases, all P＜0.05）; Logistic regression analysis showed that the onset to the surgery time（OR＝3.791, 95% CI 1.703～8.440, P＝0.001）,inadequate peritoneal drainage of intraabdominal infection（OR＝10.277, CI 1.416～73.847, P＝0.021）, the start time of postoperative enteral nutrition（OR＝46.744, 95% CI: 5.746～380.240, P＝0.000）, were the independent risk factor of early prognosis for severe abdominal infection. Conclusions Earlier operation, adequate peritoneal drainage were the premise of survival for patients, placing enteral feeding tube intra-operative, early enteral nutri⁃ tion were the most important aspects of survival for patient and organ supportment for postoperative was the primary methods, perioperative fluid management, dynamic monitoring CD4/CD8 changes were also should be taking into account.
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Received: 16 March 2016
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Corresponding Authors:
FENG Yong-wen, E-mail: boshiyy@126.com
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Address: 1 North 2nd Street,
Zhongguancun, 