|
|
|
|
|
| Clinical observation of intra-arterial thrombolysis with recombinant tissue plasminogen activator in the treatment of early acute cerebral infarction |
| WANG Yi-cui, CHANG Huan-xian, KONG Lingsheng |
| Department of Neurology, DongFang Hospital of Lianyungang City, Lianyungang 222042, China |
|
|
|
|
Abstract Objective To observe the curative effect and security of intra-arterial thrombolysis with recombinant tissue plasminogen activator （r- TPA） in the treatment of early（attack time＜6 h）acute cerebral infarction. Methods A total of 108 patients with early acute cerebral infarction were divided into two groups according to the digital table method. The observation group（54 cases, loss to follow-up 2 cases, complete 52 cases）was treated with r-TPA selective artery thrombolysis combined with interventional therapy in emergency department（Percutaneous intravascular embolectomy＋Blood vessel forming＋Stent implantation）. The control group（54 cases, loss to follow-up 2 cases, complete 52 cases）was treated with simple r-TPA intravenous thrombolysis. To observe the efficacy, complica⁃ tions and prognosis of the two groups were compared. Results The vascular patency rate of the observa⁃ tion group was 100%, the complete rate of the observation group was higher than the control group（χ2＝ 50.514, P＜0.01）. At preoperative, and 24 h, 7 d, 30 d, 3 months after surgery, the NIHSS scores in the observation group were all lower than those in the control group（all P＜0.01）. ADL scores were higher than those in the control group（all P＜0.01）. The incidence of bleeding in the observation group was lower than that in the control group（χ2＝3.9829, P＜0.05）. Follow up at 3 months after operation, the recurrence rate of cerebral infarction in the observation group was lower than that in the control group （χ2＝ 4.3789, P＜0.05）. Conclusion In the treatment of patients with early cerebral infarction,intra-arterial thrombolysis combined with endovascular treatment is superior to intravenous thrombolysis alone, improve the vascular patency rate significantly, reduce the bleeding rate, and improve the prognosis.
|
|
Received: 27 January 2016
|
| About author:: WANG Yi-cui, E-mail: wangyicuilyg@163.com |
|
|
|
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 