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| Clinical study of low dose glucocorticoid in the treatment of acute kidney injury in severe sepsis |
| IN - Lin, ZHOU Rong - bin |
| General Hospital of Beijing Military Region of Medical University of Anhui, Hefei 230000, China |
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Abstract Objective To study the effect of low dose of glucocorticoid in severe sepsis patients with acute kidney injury. Methods 55 cases of severe sepsis patients combined acute kidney injury were selected and randomly divided into glucocorticoids( GC) group( n = 29) and control group( n = 26). Both of the two groups were given the therapy of severe sepsis and low dose of GC was added. We observed and evaluated the SCr, CysC, GFR, PCT, daily urine output and the APACHEⅡ score as well as the effect of 7 days and 14 days. In addition we defined the GC group as early group of 16 cases ( < 9 hours late, the use of GC) and group of 13 cases (GC use longer than 9 hours)accord to the use of GC after the use of antibiotics. Results Onday 7, the SCr, CysC, PCT and APACHEⅡscores of patients in glucocorticoids group were significantly lower than the control group. The GFR and the urineoutputin the GC group was significantly higher than the control group. Then we analysedadrenal function and found that the renal function in patients with adrenal insufficiency was superior to those of the normal adrenal function group. Conclusion Low dose GC can improve severe sepsis patients with acute kidney injury especially who suffer the adrenal insufficiency.
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Received: 03 November 2015
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Corresponding Authors:
ZHOU Rong - bin, E - mail: dr_zhourongbin@ sina. com
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Zhongguancun, 