红玉赔赈颗粒对脓毒症患者血清MIP-2和sTREM-1的影响及其与中医症候相关性研究

doi:10.3969/j.issn.1002-1949.2019.11.013

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (11): 1074-1079 DOI: 10.3969/j.issn.1002-1949.2019.11.013

Intervention of Hongyu Compensation Granule on serum MIP-2 and sTREM-1 in sepsis patients and its correlation with TCM symptoms

Zhu Liang, Zhao Lei, Shen Meng-wen, Gu Wen-yan, Qian Yi-ming, Qian Feng-hua

Department of Emergency, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200437, China 

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Abstract Objective To investigate the effect of Hongyu Compensation Granule on serum macrophage inflammatory protein-2 (MIP-2) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in sepsis patients and the correlation between inflammatory indexes and TCM symptom scale. Methods Seventy critically ill patients who met the diagnostic criteria for sepsis were randomly divided into two groups. Test group: on the basis of routine western medicine treatment, Hongyu Compensation granules were given orally (or nasal feeding) for 7 consecutive days. Control group: on the basis of routine western medicine treatment group, 1/10 Hongyu compensatory granule placebo was added. The serum levels of MIP-2 and sTREM-1 were measured by ELISA before treatment (D0), on the first day (D1), on the third day (D3), on the seventh day (D7), and the vital signs and scores of TCM symptoms were observed and recorded. Results Before treatment, there was no significant difference in MIP-2 between the two groups (P=0.66); after treatment, the MIP-2 of the two groups decreased, and there was significant difference between the D7 groups （pg/L：78.45±41.78 vs. 111.40±72.95, P<0.05), the experimental group was better than the control group; the three test results were statistically significant compared with the same group before treatment (P<0.05). There was no significant difference in sTREM-1 between the two groups before treatment (P=0.895); after treatment, the sTREM-1 counts of the two groups decreased, and there was significant difference between the D7 groups （pg/L：112.01±40.56 vs. 150.80±53.95, P<0.05). The results of the experimental group were better than those of the control group; the results of the 7th day of treatment, the 3rd and 7th day of control group were significantly different from those of the same group before treatment (P<0.05). Before treatment, there was no significant difference in the scores of TCM symptoms between the two groups (P=0.607); after treatment, the scores of both groups decreased, and the differences between D1 and D3 groups were statistically significant （score：20.86±2.41 vs.22.25±2.26，18.57±3.37 vs. 20.17±2.21，P<0.05), the experimental group was better than the control group; D3 and D7 had statistical significance compared with the control group before treatment (P<0.05). There was a linear correlation between TCM syndrome scale and the results of serum MIP-2 and sTREM-1 test before and after treatment(P<0.05). Conclusion Serum MIP-2 and sTREM-1 are positively correlated with TCM symptoms. Hongyu Compensation Granule can help reduce the levels of serum MIP-2 and sTREM-1 inflammatory factors in patients with sepsis, inhibit excessive inflammatory reaction and improve prognosis.

Key words： Sepsis Hongyu Compensation granules Macrophage inflammatory protein-2(MIP-2) Soluble triggering receptor expressed on myeloid cells-1(sTREM-1);Chinese medicine treatment

Corresponding Authors: Qian Yi-ming, E-mail: smileqian1975@qq.com

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Cite this article:

Zhu Liang,Zhao Lei,Shen Meng-wen, et al. Intervention of Hongyu Compensation Granule on serum MIP-2 and sTREM-1 in sepsis patients and its correlation with TCM symptoms[J]. Chinese Journal of Critical Care Medicine, 2019, 39(11): 1074-1079.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.11.013 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I11/1074

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