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| The relationship between the outcome of cardiopulmonary resuscitation and the dosage of epinephrine in emergency department |
| Xu Sheng-yong, Zhu Hua-dong, Yu Xue-zhong |
| Emergency Department, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China |
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Abstract Objective To study the relationship between the outcome of cardiopulmonary resuscitation（CPR） in emergency department and the cumulative dose of epinephrine. Methods A retrospective analysis was made in all patients undergoing CPR in the emergency department of Peking Union Medical College Hospital from January 1, 2008 to June 30, 2018. The gender, age, etiology, cumulative dose of epinephrine and outcome of CPR were counted. The outcome of CPR included whether there was a return of spontaneous circulation (ROSC), whether they survived to discharge, and whether they survived to discharge with good neurologic function，among which survival to discharge with good neurologic function was the primary outcome. We analyzed the correlation between the cumulative dose of epinephrine and the outcome of CPR. Results A total of 1391 patients were enrolled in the study when there were 4843 patients with cardiac arrest during the study period. 530 patients (38.1%) hada ROSC, only 49 patients (3.5%) survived to discharge, and 35 patients (2.5%) had good neurological survival. There was a significant correlation between the cumulative dose of epinephrine> 5 mg and the poor outcome of CPR. Conclusion Patients with CPR whose epinephrine accumulated more than 5 mg had significantly deviated outcomes, and the probability of good neurological survival to discharge was zero.
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Corresponding Authors:
Zhu Hua-dong, E-mail：huadongzhu@hotmail.com
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