严重创伤患者纤溶异常的研究进展

doi:10.3969/j.issn.1002-1949.2019.02.021

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (2): 196-200 DOI: 10.3969/j.issn.1002-1949.2019.02.021

The advances of fibrinolytic abnormalities in severe trauma patients

Xu Wen-xin, Feng Qi-ming

Department of Emergency Medicine, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China

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Abstract Despite a profound up-regulation in procoagulant mechanisms, at least one-quarter of trauma patients present with trauma-induced coagulopathy. These patients usually have post injury fibrinolytic abnormalities, which is associated with an increase in mortality and worse outcomes. Fibrinolytic abnormalities include fibrinolysis shutdown and hyperfibrinolysis. The former represents a deficiency of clot degradation and increased risk of thrombosis; the later appears primarily as an excess in clot degradation. Except conventional coagulation test, the diagnosis of fibrinolytic abnormalities mainly depends on viscoelastic hemostatic assay. This review covers the most recent evidence and advances in fibrinolytic abnormalities, which provides a new idea on the diagnosis and treatment for severe trauma patients with it.

Key words： Fibrinolysis shutdown Hyperfibrinolysis Trauma-induced coagulopathy(TIC) Thrombelastography(TEG)

Corresponding Authors: Feng Qi-ming, E-mail：fengqiming04@126.com

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Xu Wen-xin,Feng Qi-ming. The advances of fibrinolytic abnormalities in severe trauma patients[J]. Chinese Journal of Critical Care Medicine, 2019, 39(2): 196-200.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.02.021 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I2/196

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