中重度ARDS时去甲肾上腺素与TNF-α IL-1βIL-9 IL-15的关系研究

doi:10.3969/j.issn.1002-1949.2018.12.015

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (12): 1086-1090 DOI: 10.3969/j.issn.1002-1949.2018.12.015

The study of the relationship between norepinephrine and TNF-α IL-1β IL-9 and IL-15 in critical ARDS

Chai Ya-ge, Peng Peng, Li Wen-li, Yang Jian-zhong

Department of Emergency, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 830054, China

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Abstract Objective Through the relationship study of TNF-α, IL-1β, IL-9, IL-15 and norepinephrine (NE) in the patients on the first day and the third day when they had been diagnosed as acute respiratory distress syndrome (ARDS), we aim to explore the neuro-immune pathogenesis of ARDS. Methods We had chosen 28 ARDS patients as the case group between June 2013 to November 2015 from the Department of Emergency of the First Affiliated Hospital of Xinjiang Medical University. According to the survival of patients after the twenty-eighth day, we also divided the case group into non-survival group (n=15) and survival group (n=13). And we had chosen 22 healthy people as the control group. We respectively tested the plasma NE, TNF-α, IL-1β, IL-9 and IL-15 concentration in the case group on the first day and the third day, and tested the same index in the control group on the first day. And then we analyzed the data. Results On the first day and the third day, the level of IL-1β, IL-9, IL-15, NE was higher than that of the control group (P＜0.05). On the first day NE showed a positive correlation with the TNF-α, IL-1β, IL-9 (P＜0.05, r＞0), and a negative correlation with the IL-15 (P＜0.05, r＜0); on the third day NE showed a positive correlation with the TNF-α (P＜0.05, r＞0). On the first day the level of the non-survival group about IL-9（4.45±0.51）, IL-15（115.37±18.59） and NE （18.45±3.23）pg/mL was higher than that of the survival group ［3.88±0.33, 88.69±12.35, (17.97±3.35)pg/mL, P＞0.05］, the TNF-α(219.57±35.36)and IL-1β(197.16±32.27) level of non-survival group was distinctly higher than that of the survival group (168.42±21.96,138.05±24.73,P＜0.05). Logistic regression analysis showed that TNF-α(OR=1.004, 95%CI2.18~10.25, P=0.003) and IL-1β (OR=1.005, 95%CI 1.79~8.69, P=0.013) were the risk factors that affected the prognosis of ARDS. Conclusion The SNS transmitters releasing is correlated to the change of the inflammatory factors. Therefore, in the course of clinical diagnosis and treatment, we should pay more attention to the activity changes of sympathetic nerve.

Key words： Acute respiratory distress syndrome (ARDS) Norepinephrine(NE) Inflammatory factors

Corresponding Authors: Yang Jian-zhong, E-mail: yjz6542@126.com

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Cite this article:

Chai Ya-ge,Peng Peng,Li Wen-li, et al. The study of the relationship between norepinephrine and TNF-α IL-1β IL-9 and IL-15 in critical ARDS[J]. Chinese Journal of Critical Care Medicine, 2018, 38(12): 1086-1090.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2018.12.015 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I12/1086

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