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| The effect of norepinephrine combined with sodium phosphocreatine on the early cardiac function of patients with septic shock |
| Kang Da-wei, Yu Jian, Ju Ming-fei |
| Department of Emergency, the Affiliated Hospital of Chengde Medical College, Chengde 067000, China |
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Abstract Objective To investigate the effects of norepinephrine(NS) combined with sodium phosphocreatine(SP) on the early heart function of patients with septic shock. Methods A prospective cohort study was conducted in 40 patients suffering from septic shock with the duration <24 hours admitted to the Emergency Department of Chengde Medical College Affiliated Hospital during May 2016 to May 2017. The patients were randomly divided into NS group (n=20)and NS+SP group (n=20). The patients were observed ejection fraction (EF%), brain natriuretic peptide (BNP), cardiac troponin T (cTnT), lactate (Lac), and Marshall heart score (PAR value) 0, 24, 72 h of admission; correlation of BNP, cTnT and EF% was analyzed; 28-day survival analysis was also done. Results ①Compared with the 0 h, at 24 h EF% increased significantly (P<0.01), BNP, cTnT, Lac, PAR decreased significantly (P<0.01). Compared with NS group, EF%, Lac and PAR had no obvious abnormalities(P>0.05), BNP, cTnT decreased significantly in NS+SP group(P<0.01). ②Compared with the NS group at 72 h, the EF% increased significantly (P<0.01), BNP, cTnT, Lac and PAR decreased significantly (P<0.01). ③BNP and cTnT were significantly negatively correlated with EF% (P<0.01). ④ Compared with the 28-day survival rate in NS group, the increase of NS+SP group was significant (P<0.05). Conclusion SP can be used to improve the cardiac function of sepsis at the early stage with NS. This mechanism may reduce the expression of BNP and cTnT.
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| About author:: Kang Da-wei, E-mail: kdwstrive@163.com |
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