CRRT联合ECMO对犬ARDS肺保护作用的实验研究

doi:10.3969/j.issn.1002-1949.2018.01.019

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (1): 84-88 DOI: 10.3969/j.issn.1002-1949.2018.01.019

Protective effect of CRRT combined with ECMO against acute respiratory distress syndrome (ARDS) in canines

He Yu-qin, Mei Xue, Shang Ming-xu, Zhang Jing-jing, Zhan Qing-yuan

Department of Emergency, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China

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Abstract Objective: To investigate the mitigation of continuous renal replacement therapy (CRRT) to extracorporeal membrane oxygenation related systemic inflammatory response syndrome (ECMO-related SIRS) and the lung protection against acute respiratory distress syndrome (ARDS) in canines. Methods: Thirty adult canines were randomly divided into four groups: control group; sham group, ECMO (EC) group, ECMO+CRRT (EC+CR) group. Nine points of blood specimen of IL-6 and TNF-α during treatment and homogenate of lungs after treatment were examined. Pathology specimen of canine lung according to gravity dependent or non-gravity dependent space was attained; the lungs tissue wet/dry ratio was assessed. Results: Serum inflammatory cytokines (IL-6, TNF-α) significantly increased after the start of treatment. Compared with EC group, the concentration of IL-6 and TNF-α in EC+CR group decreased after 2～4 hours and 1～2 hours respectively (P<0.05). The pathology score and wet/dry ratio indicated that EC+CR was better than EC group, the lung tissue homogenates revealed that there was a significance between EC group and EC+CR group about inflammatory cytokines (P<0.05). Conclusion: In the ECMO-related SIRS-aggravated lung injury model, there is a certain mitigate effect on ECMO-related SIRS by CRRT, and there might be an alleviated effect to lung injury.

Received: 27 July 2017

Corresponding Authors: Zhan Qing-yuan, E-mail: zhanqy0915@163.com

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	He Yu-qin
	Mei Xue
	Shang Ming-xu
	Zhang Jing-jing
	Zhan Qing-yuan

Cite this article:

He Yu-qin,Mei Xue,Shang Ming-xu, et al. Protective effect of CRRT combined with ECMO against acute respiratory distress syndrome (ARDS) in canines[J]. Chinese Journal of Critical Care Medicine, 2018, 38(1): 84-88.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2018.01.019 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I1/84

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