Objective To compare the application value of rapid sequential organ failure score (qSOFA) and rapid emergency medical score (REMS) in predicting the prognosis of severe patients in emergency department. Methods The qSOFA score and REMS score were recorded in 1647 patients after they admitted to the emergency resuscitation department, the differences of both scores between survival group and death group were analyzed, and area under ROC curve was used to evaluate the accuracy of both scores in predicting the patients outcomes. Results With the scores increased, the mortality rate increased. The area under the ROC curve of qSOFA score and REMS score were 0.739 and 0.7, respectively, which were significantly different from AUC=0.5. Conclusion The qSOFA score is not only applicable to the infected patients. It can predict the risk of death for all emergency critical patients. qSOFA score just needs three parameters, which is more suitable for the initial assessment in emergency, rather than other complex scores.