Objective To analyze the related factors of restoration of spontaneous circulation (ROSC) and survival ratio after cardiopulmonary resuscitation (CPR) in pre-hospital cardiac arrest patients, and to provide evidence for improving the success rate of pre-hospital resuscitation. Methods We followed up and retrospectively analyzed 117 successful resuscitation cases of pre-hospital cardiac arrest and statistically analyzed the related influencing factors. Results 11 cases (9.4%) were survival and discharged from the hospital while 106 cases died after ROSC. There were significant differences (P<0.05) in cardiogenic disease, Witness-CPR, less than 4 min first aid response time between the discharge group and the death group. Fact of VF/VT before resuscitation in discharge group was significantly higher than that in death group(P<0.01). First aid response time, duration of CPR and adrenaline dose had negative correlation with the discharge rate. There was no statistical difference in cardiac rhythm after resuscitation and defibrillation times. There was a statistically significant difference between using mask ventilation and endotracheal intubation who has lower discharge rate. Conclusion VF/VT before resuscitation, first aid response time and duration of CPR may be important factors affecting the success rate of pre-hospital cardiopulmonary resuscitation and the rate of hospital discharge. Patients with low doses of epinephrine and mask ventilation may have an ideal prognosis for resuscitation.