|
|
|
|
|
| In-hospital and long-term mortality in patients with ST-elevation myocardial infarction is asso-
ciated with serum potassium level |
| SHU Jin，YANG Tian- he |
| Department of Cardiology，Guizhou Province People's Hospital，Guiyang 550002，China |
|
|
|
|
Abstract Objective To figure out the relation between admission serum potassium（sK）level and in-hospital
and long-term mortality and ventricular arrhythmias. Methods Retrospectively，298 patients with
ST-elevation myocardial infarction（STEMI）who underwent primary percutaneous coronary intervention were recruited. According to admission sK levels they were divided into 5 groups: sK＜3.5，3.5≤sK＜4，4≤sK＜4.5，4.5≤sK＜5，and sK≥5 mmol/L. Results The lowest in-hospital andlong- term mortality
occurred in patients with sK levels of 3.5≤sK＜4 mmol/L. 4.5≤sK＜5 mmol/L group with in-hospital
mortality（OR＝1.89，95% CI 1.28~7.41，P＝0.028）and follow-up mortality（OR＝2.65，95% CI 1.81~8.69，P＝0.015），were respectively 1.89 times and 2.65 times than 3.5≤sK＜4 mmol/L group. Patients in sK＜3.5 mmol/L group（OR＝2.49，95% CI 1.94~6.55，P＝0.003）and sK≥5 mmol/L group（OR＝4.70，95% CI
1.70~13.55，P＝0.045）have significantly increased risk of ventricular arrhythmias. Conclusion
Admission sK level of ≥4.5 mmol/L is associated with increased long-term mortality in STEMI. A
significant relation is found between sK level of ＜3.5 mmol/L and ≥5 mmol/L and ventricular
arrhythmias.
|
|
Received: 19 January 2016
|
| About author:: SHU Jin，E-mail：shujingz01@sina.com |
|
|
|
| [1] 张会，周长钰，富华颖，等. 急性心肌梗死患者早期血钾水平及相关因素分析[J]. 中国慢性病预防与控制，2011，19（3）: 286-288.
[2] Mozos I. Laboratory markers of ventricular arrhythmia risk in renal failure[J]. Biomed Res Int，2014，
2014: 509204.
[3] Reno CM，Daphna-Iken D，Chen YS，et al. Severe hypoglycemia-induced lethal cardiac arrhythmias are
mediated by sympathoadrenal activation[J]. Diabetes，2013，62（10）: 3570-3581.
[4] Dawes M，Sieniawska C，Delves T，et al. Barium reduces resting blood flow and inhibits potassium-induced
vasodilation in the human forearm[J]. Circulation，2002，105（11）: 1323-1328.
[5] Sekiyama H，Nagoshi T，Komukai K，et al. Transient decrease in serum potassium level during ischemic
attack of acute coronary syndrome: paradoxical contribution of plasma glucose level and glyco⁃hemoglobin[J].
Cardiovasc Diabetol，2013，12: 4.
[6] Macdonald JE，Struthers AD. What is the optimal serum potassium level in cardiovascular patients[J].
J Am Coll Cardiol，2004，43（2）: 155-161.
[7] Goyal A，Spertus JA，Gosch K，et al. Serum potassium levels and mortality in acute myocardial infarction [J]. JAMA，2012，307（2）:157-164.
[8] Choi JS，Kim YA，Kim HY，et al. Relation of serum potassium level to long- term outcomes in patients with
acute myocardial infarction[J]. Am J Cardiol，2014，113（8）: 1285-1290.
[9] 彭燚焱. 急性心肌梗死患者中儿茶酚胺浓度对病情发展的影响[J]. 中国医药科学，2013，3（2）:188-189.
[10] 李勇，吕树铮，马临安，等. ST 段抬高型心肌梗死患者血钾水平与原发性恶性室性心律失常的相关研究[J]. 现代生物医学进展，2010，13（13）: 2469-2472.
[11] Park KL，Goldberg RJ，Anderson FA，et al. GRACE Investigators.Beta- blocker Use in ST- segment Elevation
Myocardial Infarction in the Reperfusion Era（GRACE）[J]. Am J Med，2014，127（6）:503-511.
[12] Ekmekçi A，Uluganyan M，Tufan F，et al. Impact of admission blood glucose levels on prognosis of elderly
patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention[J].
J Geriatr Cardiol，2013，10（4）: 310-316.
[13] Ekmekci A，Cicek G，Uluganyan M，et al. Admission hyperglycemia predicts inhospital mortality and major
adverse cardiac events after primary percutaneous coronary intervention in patients without diabetes
mellitus[J]. Angiology，2014，65（2）: 154-159.
[14] Bae EH，Lim SY，Cho KH，et al. GFR and cardiovascular outcomes after acute myocardial infarction: results from the Korea Acute Myocardial Infarction Registry[J]. Am J Kidney Dis，2012，59（6）: 795-802. |
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 
