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| Clinic study of early postoperative application of CRRT in severely electric burned patients |
| Liu Wei, Xu Zhao-Rong, Chen Zhao-Hong |
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Abstract Objective To investigate early postoperative application of continuous renal replacement therapy（CRRT）contributing to severely electric burned patients. Methods The clinical characteristics of forty-three patients with severely electric burn were collected and randomly divided into traditional group and CRRT group, twenty-two patients acquire postoperative CRRT and twenty-two patients in traditional therapy. The inflammatory cytokines IL- 1β, TNF- α and myoglobin in serum of the patients in both groups were detected in preoperative and postoperative（1 h and 72 h after operation）time. Complications and results of two methods were analyzed retrospectively. Results Two groups had no differences in occurrence rate of acute renal failure（χ2＝0.616, P＝0.4325＞0.05）. IL-1β, TNF-normally increased in both groups and rose a lot more after operation（1 h）, while decreased within 72 h after operation. IL- 1β and TNF-α in CRRT group dropped a lot more compared with traditional group（t＝15.916, 9.522, P＜0.05）. Myoglobin in both groups came down after burn by degrees, and CRRT group decreased more compared with traditional group（t＝9.208, P＜0.05）; there were differences in the occurrence of sepsis and MODS（sepsis χ2＝6.776, P＝0.0209＜0.05; MODS χ2＝6.435, P＝0.011＜0.05）, and no difference in mortality of both groups . Conclusion CRRT can relieve the symptom of inflammatory and risk of MODS by cleaning up inflammatory factors and toxin effectively, yet have no differences in mortality.
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Received: 11 July 2016
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