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| The correlation between leptin to adiponectin ratio in serum and cognitive impairment of acute stroke patients |
| JIN Ting, SONG Rong-Rong, HAN Ya |
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Abstract Objective To explore the correlation between leptin to adiponectin ratio（L/A ratio）in serum and cognitive impairment of acute stroke patients. Methods We collected 128 acute stroke patients during September 2014 to September 2015. We examined the serum levels of L/A ratio when they suffered from acute stroke, and divided the patients into VaD group（n＝24）, VCI group（n＝37）and control group（n＝67）according to MMSE scores, MoCA scores and the criteria we used after 3 months. Results The L/A ratio of VaD group was higher than that of VCI group, and both were higher than the ratio of control group. The difference was statistical significant（Ｐ＜0.05）. The L/A ratio was negatively related to MMSE scores（r＝-0.464, Ｐ＜0.05）, and MoCA scores（r＝-0.519,Ｐ＜0.05）. In addition,the area under curve of ROC was 0.771, which indicated relatively high diagnosis accuracy. The best cutoff level of L/A ratio was 1.76. Conclusion The serum L/A ratio of acute stroke patients was positively related to severity of cognitive impairment, and might be helpful for the diagnosis of post-stroke cognitive impairment.
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Received: 25 July 2016
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