Objective To investigate independent electrocardiogram (ECG) risk predictors for patients with acute anterior myocardial infarction treated with percutaneous coronary intervention and to establish its ECG prognostic model. Methods 213 patients with acute anterior myocardial infarction treated with percutaneous coronary intervention were included in this study. According to the ECG parameters of patients at discharge, COX regression models was performed to determine ECG risk predictors and a ECG risk score was established for these patients. Results The primary composite adverse clinical events occurred in 19.25% of the 213 patients, and the mean follow-up period was (12.05±2.52) months. On Cox regression analysis, ventricular premature contraction (P=0.004), QRS duration ≥110 ms (P=0.002), QT dispersion ≥80 ms (P=0.029) and fragmented QRS complex (P=0.026) were the risk predictors of the primary composite adverse clinical events in this study. Based on the ECG risk score, the patients were divided into 0-2 score group and >2 score group. The incidence of the primary composite adverse clinical events was significantly higher in >2 score group than that in 0～2 score group. Conclusion ECG QRS duration≥110 ms, QT dispersion≥80 ms, fragmented QRS complex and ventricular premature contraction at discharge are independent risk predictors in patients with acute anterior myocardial infarction treated with percutaneous coronary intervention in this study. ECG risk score established in this study shows a certain prognostic value.