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| The risk factors for carbapenem-resistance of klebsiella pneumoniae isolated from lower respira-
tory tract in ICU |
| ZHANG Bei- lei，LIN Jian- dong，LIAO Xiu- yu，CHEN Xiao- li |
| Department of ICU，The First Affiliated Hospital of Fujian Medical University，Fuzhou 350005，China |
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Abstract Objective To investigate the antibiotic resistance of klebsiella pneumoniae isolated from lower
respiratory tract in ICU and the risk factors of carbapenem-resistant，so as to provide reference
for making preventive and control measures of carbapenem-resistant klebsiella pneumoniae（CRKP）
infection. Methods The klebsiella pneumoniae isolated from sputum samples of patients with lower
respiratory tract infection from April 2013 to April 2015 in ICU were cultured to analyze the drug
resistance and clinical data of those patients who were collected to analyze the risk factors of
CRKP infection. Results ①The sensitive rate of Amikacin was the highest，which accounted for
86.81％，followed by imipenem and meropenem which accounted for 62.5% and 62.86%，respectively. Of 153 strains of isolated klebsiella pneumonia，56（36.7％）were CRKP. Among the CRKP isolated，the sensitive rate of Amikacin was the highest，which accounted for 68.52%，followed by cotrimoxazole，which accounted for 25%. The resistant rates of other antimicrobial agents were less than 20%. The resistance was very serious.②Univariate analysis revealed that length of hospital stay≥5 days，ICU
occupancy≥7 days，the length of mechanical ventilation≥7 days，use of urinary catheterization，use of Carbapenem antibiotics within 2 weeks，WBC＞10.0×109/L or＜4.0×109/L，the presence of fungal
infection at the same time and hypertension were risk factors for carbapenem-resistant. Logistic
regression analysis revealed that length ofhospital stay≥5 days and use of carbapenem antibiotics
within 2 weeks were independent risk factors for CRKP infection. Conclusion The resistance of
klebsiella pneumoniae was very serious in ICU.Reducing the use of carbapenem antibiotics and
shortening the length of hospital stay may help to prevent the lower respiratory tract infections
caused by CRKP.
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Received: 03 August 2015
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| About author:: ZHANG Bei-lei, E-mail: rosensand7@aliyun.com |
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